Abstract
Introduction: The changes in glycan structures have been attributed to disease states for several decades. The surface glycosylation pattern is a signature of physiological state of a cell. In this review we provide a link between observed substructural glycan changes and a range of diseases.
Areas covered: We highlight biologically relevant glycan substructure expression in cancer, inflammation, neuronal diseases and diabetes. Furthermore, the alterations in antibody glycosylation in a disease context are described.
Expert commentary: Advances in technologies, as described in Part 1 of this review have now enabled the characterization of specific glycan structural markers of a range of disease states. The requirement of including glycomics in cross-disciplinary omics studies, such as genomics, proteomics, epigenomics, transcriptomics and metabolomics towards a systems glycobiology approach to understanding disease mechanisms and management are highlighted.
| Original language | English |
|---|---|
| Pages (from-to) | 341-352 |
| Number of pages | 12 |
| Journal | Expert Review of Proteomics |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2018 |
Keywords
- Glycomics
- glycan structure
- glycan analysis
- mass spectrometry
- disease glycomics
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