Human stimulus factor is a promising peptide for delivery of therapeutics

Mehra Haghi; Norbert Windhab; Benedikt Hartwig; Paul M. Young; Daniela Traini

doi:10.1016/j.xphs.2018.11.017

Human stimulus factor is a promising peptide for delivery of therapeutics

Mehra Haghi, Norbert Windhab, Benedikt Hartwig, Paul M. Young, Daniela Traini^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Fluticasone propionate uptake in the presence of a proprietary cell-penetrating peptide (human stimulus factor, [HSF]) based on the N-terminal domain of lactoferrin was studied, alone and in combination with salmeterol, using an air interface Calu-3 epithelial model. The HSF enhanced uptake and transport of fluticasone propionate across the epithelial barrier when alone and in presence of salmeterol. This was attributed to transcellular-mediated uptake. This HSF is a promising peptide for delivery of therapeutics where enhanced epithelial penetrating is required.

Original language	English
Pages (from-to)	1401-1403
Number of pages	3
Journal	Journal of Pharmaceutical Sciences
Volume	108
Issue number	4
DOIs	https://doi.org/10.1016/j.xphs.2018.11.017
Publication status	Published - Apr 2019
Externally published	Yes

Keywords

cell transport
cell-penetrating peptide
corticosteroids
human stimulus factor
inhaler

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10.1016/j.xphs.2018.11.017

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title = "Human stimulus factor is a promising peptide for delivery of therapeutics",

abstract = "Fluticasone propionate uptake in the presence of a proprietary cell-penetrating peptide (human stimulus factor, [HSF]) based on the N-terminal domain of lactoferrin was studied, alone and in combination with salmeterol, using an air interface Calu-3 epithelial model. The HSF enhanced uptake and transport of fluticasone propionate across the epithelial barrier when alone and in presence of salmeterol. This was attributed to transcellular-mediated uptake. This HSF is a promising peptide for delivery of therapeutics where enhanced epithelial penetrating is required.",

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author = "Mehra Haghi and Norbert Windhab and Benedikt Hartwig and Young, {Paul M.} and Daniela Traini",

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language = "English",

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AU - Haghi, Mehra

AU - Windhab, Norbert

AU - Hartwig, Benedikt

AU - Young, Paul M.

AU - Traini, Daniela

PY - 2019/4

Y1 - 2019/4

N2 - Fluticasone propionate uptake in the presence of a proprietary cell-penetrating peptide (human stimulus factor, [HSF]) based on the N-terminal domain of lactoferrin was studied, alone and in combination with salmeterol, using an air interface Calu-3 epithelial model. The HSF enhanced uptake and transport of fluticasone propionate across the epithelial barrier when alone and in presence of salmeterol. This was attributed to transcellular-mediated uptake. This HSF is a promising peptide for delivery of therapeutics where enhanced epithelial penetrating is required.

AB - Fluticasone propionate uptake in the presence of a proprietary cell-penetrating peptide (human stimulus factor, [HSF]) based on the N-terminal domain of lactoferrin was studied, alone and in combination with salmeterol, using an air interface Calu-3 epithelial model. The HSF enhanced uptake and transport of fluticasone propionate across the epithelial barrier when alone and in presence of salmeterol. This was attributed to transcellular-mediated uptake. This HSF is a promising peptide for delivery of therapeutics where enhanced epithelial penetrating is required.

KW - cell transport

KW - cell-penetrating peptide

KW - corticosteroids

KW - human stimulus factor

KW - inhaler

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AN - SCOPUS:85059348404

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SP - 1401

EP - 1403

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

IS - 4

ER -

Human stimulus factor is a promising peptide for delivery of therapeutics

Abstract

Keywords

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