Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose‐related oxidative stress

Anne Voigt, Herbert F. Jelinek

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    Mitochondrial RNR‐2 (mt‐RNR2, humanin) has been shown to play a role in protecting several types of cells and tissues from the effects of oxidative stress. Humanin (HN) functions through extracellular and intracellular pathways adjusting mitochondrial oxidative phosphorylation and ATP production. Addition of HN improved insulin sensitivity in animal models of diabetes mellitus but no clinical studies have been carried out to measure HN levels in humans associated with hyperglycemia. The plasma levels of HN in participants attending a diabetes complications screening clinic were measured. Clinical history and anthropometric data were obtained from all participants. Plasma levels of HN were measured by a commercial ELISA kit. All data were analyzed applying nonparametric statistics and general linear modeling to correct for age and gender. A significant decrease (P = 0.0001) in HN was observed in the impaired fasting glucose (IFG) group (n = 23; 204.84 ± 92.87 pg mL⁻¹) compared to control (n = 58; 124.3 ± 83.91 pg mL⁻¹) consistent with an adaptive cellular response by HN to a slight increase in BGL.
    Original languageEnglish
    Article numbere12796
    Pages (from-to)1-5
    Number of pages5
    JournalPhysiological Reports
    Issue number9
    Publication statusPublished - May 2016

    Bibliographical note

    Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


    • Humanin
    • impaired fasting glucose
    • mitochondrial adaptation
    • mt-RNR2
    • oxidative stress


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