Hydrogels with intrinsic antibacterial activity prepared from naphthyl anthranilamide (NaA) capped peptide mimics

Vina R. Aldilla; Renxun Chen; Rajesh Kuppusamy; Sudip Chakraborty; Mark D. P. Willcox; David St C. Black; Pall Thordarson; Adam D. Martin; Naresh Kumar

doi:10.1038/s41598-022-26426-1

Hydrogels with intrinsic antibacterial activity prepared from naphthyl anthranilamide (NaA) capped peptide mimics

Vina R. Aldilla, Renxun Chen^*, Rajesh Kuppusamy, Sudip Chakraborty, Mark D. P. Willcox, David St C. Black, Pall Thordarson, Adam D. Martin, Naresh Kumar

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

93 Downloads (Pure)

Abstract

In this study, we prepared antibacterial hydrogels through the self-assembly of naphthyl anthranilamide (NaA) capped amino acid based cationic peptide mimics. These ultra-short cationic peptide mimics were rationally designed with NaA as a capping group, l-phenylalanine, a short aliphatic linker, and a cationic group. The synthesized peptide mimics efficiently formed hydrogels with minimum gel concentrations between 0.1 and 0.3%w/v. The resulting hydrogels exhibited desirable viscoelastic properties which can be tuned by varying the cationic group, electronegative substituent, or counter anion. Importantly, nanofibers from the NaA-capped cationic hydrogels were found to be the source of hydrogels’ potent bacteriacidal actvity against both Gram-positive and Gram-negative bacteria while remaining non-cytotoxic. These intrinsically antibacterial hydrogels are ideal candidates for further development in applications where bacterial contamination is problematic.

Original language	English
Article number	22259
Pages (from-to)	1-12
Number of pages	12
Journal	Scientific Reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41598-022-26426-1
Publication status	Published - 23 Dec 2022

Bibliographical note

Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Access to Document

10.1038/s41598-022-26426-1Licence: CC BY

Publisher version (open access)Final published version, 1.72 MBLicence: CC BY

Cite this

@article{af779a1a561e4c78aefd116131001cb6,

title = "Hydrogels with intrinsic antibacterial activity prepared from naphthyl anthranilamide (NaA) capped peptide mimics",

abstract = "In this study, we prepared antibacterial hydrogels through the self-assembly of naphthyl anthranilamide (NaA) capped amino acid based cationic peptide mimics. These ultra-short cationic peptide mimics were rationally designed with NaA as a capping group, l-phenylalanine, a short aliphatic linker, and a cationic group. The synthesized peptide mimics efficiently formed hydrogels with minimum gel concentrations between 0.1 and 0.3%w/v. The resulting hydrogels exhibited desirable viscoelastic properties which can be tuned by varying the cationic group, electronegative substituent, or counter anion. Importantly, nanofibers from the NaA-capped cationic hydrogels were found to be the source of hydrogels{\textquoteright} potent bacteriacidal actvity against both Gram-positive and Gram-negative bacteria while remaining non-cytotoxic. These intrinsically antibacterial hydrogels are ideal candidates for further development in applications where bacterial contamination is problematic.",

author = "Aldilla, {Vina R.} and Renxun Chen and Rajesh Kuppusamy and Sudip Chakraborty and Willcox, {Mark D. P.} and Black, {David St C.} and Pall Thordarson and Martin, {Adam D.} and Naresh Kumar",

note = "Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2022",

month = dec,

day = "23",

doi = "10.1038/s41598-022-26426-1",

language = "English",

volume = "12",

pages = "1--12",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Springer, Springer Nature",

number = "1",

}

TY - JOUR

T1 - Hydrogels with intrinsic antibacterial activity prepared from naphthyl anthranilamide (NaA) capped peptide mimics

AU - Aldilla, Vina R.

AU - Chen, Renxun

AU - Kuppusamy, Rajesh

AU - Chakraborty, Sudip

AU - Willcox, Mark D. P.

AU - Black, David St C.

AU - Thordarson, Pall

AU - Martin, Adam D.

AU - Kumar, Naresh

N1 - Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2022/12/23

Y1 - 2022/12/23

N2 - In this study, we prepared antibacterial hydrogels through the self-assembly of naphthyl anthranilamide (NaA) capped amino acid based cationic peptide mimics. These ultra-short cationic peptide mimics were rationally designed with NaA as a capping group, l-phenylalanine, a short aliphatic linker, and a cationic group. The synthesized peptide mimics efficiently formed hydrogels with minimum gel concentrations between 0.1 and 0.3%w/v. The resulting hydrogels exhibited desirable viscoelastic properties which can be tuned by varying the cationic group, electronegative substituent, or counter anion. Importantly, nanofibers from the NaA-capped cationic hydrogels were found to be the source of hydrogels’ potent bacteriacidal actvity against both Gram-positive and Gram-negative bacteria while remaining non-cytotoxic. These intrinsically antibacterial hydrogels are ideal candidates for further development in applications where bacterial contamination is problematic.

AB - In this study, we prepared antibacterial hydrogels through the self-assembly of naphthyl anthranilamide (NaA) capped amino acid based cationic peptide mimics. These ultra-short cationic peptide mimics were rationally designed with NaA as a capping group, l-phenylalanine, a short aliphatic linker, and a cationic group. The synthesized peptide mimics efficiently formed hydrogels with minimum gel concentrations between 0.1 and 0.3%w/v. The resulting hydrogels exhibited desirable viscoelastic properties which can be tuned by varying the cationic group, electronegative substituent, or counter anion. Importantly, nanofibers from the NaA-capped cationic hydrogels were found to be the source of hydrogels’ potent bacteriacidal actvity against both Gram-positive and Gram-negative bacteria while remaining non-cytotoxic. These intrinsically antibacterial hydrogels are ideal candidates for further development in applications where bacterial contamination is problematic.

UR - http://www.scopus.com/inward/record.url?scp=85144638069&partnerID=8YFLogxK

U2 - 10.1038/s41598-022-26426-1

DO - 10.1038/s41598-022-26426-1

M3 - Article

C2 - 36564414

AN - SCOPUS:85144638069

SN - 2045-2322

VL - 12

SP - 1

EP - 12

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 22259

ER -

Hydrogels with intrinsic antibacterial activity prepared from naphthyl anthranilamide (NaA) capped peptide mimics

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this