Hydrogen peroxide modulation of the respiratory burst of human neutrophils

Jacqueline S. Winn*, Jennifer Guille, Janusz M. Gebicki, Richard O. Day

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Addition of micromolar concentrations of hydrogen peroxide (H2O2) to human neutrophils resulted in a dose-dependent luminol-enhanced chemiluminescent response. Pretreatment of neutrophils with micromolar concentrations of H2O2 altered their response to the surface acting stimulants serumtreated zymosan (STZ) and formyl-methionyl-leucyl-phenylalanine (fMLP), but not to the intracellular stimulant phorbol myristate acetate (PMA). The alterations were partially reversible by catalase, but exacerbated by Superoxide dismutase. These results suggest a modulatory role for H2O2 in the respiratory burst of neutrophils.

Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalBiochemical Pharmacology
Volume41
Issue number1
DOIs
Publication statusPublished - 1 Jan 1991

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