Hypercalcaemia in small cell lung cancer: Report of a case associated with parathyroid hormone-related protein (PTHrP)

R. Stuart-Harris, V. Ahern, J. A. Danks, H. Gurney, T. J. Martin

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Although hypercalcaemia is frequently associated with malignancy, it is very rare in small cell lung cancer despite the high incidence of lytic bone metastases. We report a patient with extensive small cell cancer who presented with hypercalcaemia. Investigations suggested parathyroid hormone (PTH) receptor stimulation, although the serum PTH level was not elevated. PTH related protein (PTHrP) was localised in a biopsy specimen from the tumour. Although hypercalcaemia is rare in small cell lung cancer, when hypercalcaemia does occur, PTHrP may be a causal factor.

LanguageEnglish
Pages1601-1604
Number of pages4
JournalEuropean Journal of Cancer
Volume29
Issue number11
DOIs
Publication statusPublished - 1993
Externally publishedYes

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Parathyroid Hormone-Related Protein
Small Cell Lung Carcinoma
Hypercalcemia
Parathyroid Hormone Receptor Type 1
Neoplasms
Parathyroid Hormone
Neoplasm Metastasis
Biopsy
Bone and Bones
Incidence
Serum

Cite this

Stuart-Harris, R. ; Ahern, V. ; Danks, J. A. ; Gurney, H. ; Martin, T. J. / Hypercalcaemia in small cell lung cancer : Report of a case associated with parathyroid hormone-related protein (PTHrP). In: European Journal of Cancer. 1993 ; Vol. 29, No. 11. pp. 1601-1604.
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Hypercalcaemia in small cell lung cancer : Report of a case associated with parathyroid hormone-related protein (PTHrP). / Stuart-Harris, R.; Ahern, V.; Danks, J. A.; Gurney, H.; Martin, T. J.

In: European Journal of Cancer, Vol. 29, No. 11, 1993, p. 1601-1604.

Research output: Contribution to journalArticleResearchpeer-review

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