TY - JOUR
T1 - Hypercalcaemia in small cell lung cancer
T2 - Report of a case associated with parathyroid hormone-related protein (PTHrP)
AU - Stuart-Harris, R.
AU - Ahern, V.
AU - Danks, J. A.
AU - Gurney, H.
AU - Martin, T. J.
PY - 1993
Y1 - 1993
N2 - Although hypercalcaemia is frequently associated with malignancy, it is very rare in small cell lung cancer despite the high incidence of lytic bone metastases. We report a patient with extensive small cell cancer who presented with hypercalcaemia. Investigations suggested parathyroid hormone (PTH) receptor stimulation, although the serum PTH level was not elevated. PTH related protein (PTHrP) was localised in a biopsy specimen from the tumour. Although hypercalcaemia is rare in small cell lung cancer, when hypercalcaemia does occur, PTHrP may be a causal factor.
AB - Although hypercalcaemia is frequently associated with malignancy, it is very rare in small cell lung cancer despite the high incidence of lytic bone metastases. We report a patient with extensive small cell cancer who presented with hypercalcaemia. Investigations suggested parathyroid hormone (PTH) receptor stimulation, although the serum PTH level was not elevated. PTH related protein (PTHrP) was localised in a biopsy specimen from the tumour. Although hypercalcaemia is rare in small cell lung cancer, when hypercalcaemia does occur, PTHrP may be a causal factor.
UR - http://www.scopus.com/inward/record.url?scp=0027304709&partnerID=8YFLogxK
U2 - 10.1016/0959-8049(93)90304-X
DO - 10.1016/0959-8049(93)90304-X
M3 - Article
C2 - 8217368
AN - SCOPUS:0027304709
SN - 0959-8049
VL - 29
SP - 1601
EP - 1604
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 11
ER -