Hyperglycaemia, oxidative stress and inflammatory markers

Eugene G. Butkowski*, Herbert F. Jelinek

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Introduction: The increasing prevalence of hyperglycaemia implicates a state of oxidative stress and inflammation. Traditional and emerging biomarkers associated with increasing hyperglycaemia were assessed to clarify their role they play in hyperglycaemia. Results: 309 participants attending a rural diabetic screening program were categorised into control and quintile groups based upon glucose levels: 1st quintile - <4.5 mmol/L and 4th, 5th quintile - >6.1 mmol/L. Significant results were obtained for anthropometric data and biochemical markers - glucose, HbA1c and total cholesterol (P < 0.001); oxidative stress: glutathione (P < 0.001), glutathione:glutathione disulfide and 8-hydroxy-2-deoxyguanosine (P < 0.05). Interleukin -1β and inflammatory marker ratios IL-6/IL-10, IL-1β/IL-10, MCP-1/IL-10, IGF-1/IL-10 and IL-6/IL-1β were significant (P < 0.05). Conclusion: This study provided further evidence that inflammatory and oxidative stress biomarkers may contribute to diagnostic information associated with preclinical increases in BGL. Further we have provided a unique study in the analysis of ratios of inflammatory biomarkers and correlations with increasing BGL.

Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalRedox Report
Volume22
Issue number6
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • 8-hydroxy-2′-deoxyguanosine
  • body mass index
  • cardiovascular disease
  • glutathione
  • glutathione disulphide
  • impaired fasting glucose
  • insulin like growth factor 1
  • interleukin 10
  • interleukin 1β
  • interleukin-6
  • monocyte chemoattractant protein 1
  • oxidative stress
  • prediabetes
  • risk factors
  • Type 2 diabetes mellitus

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