Hyperinsulinism and overgrowth without obesity

S. Srinivasan, M. J. Waters, J. E. Rowland, R. C. Baxter, C. F. Verge*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


We report a 5 year old girl with postnatal overgrowth (height velocity >97th centile), hyperinsulinaemia, and increased insulin-like growth factor 1 for age, without evidence of bioactive or immunoreactive growth hormone excess or pituitary abnormality. Although her overgrowth may be a result of hyperinsulinism, her serum contains a factor (neither insulin nor IGF-1) which is able to stimulate the proliferation of lymphocyte precursors, and this could also account for the overgrowth. Over the course of two years observation she has developed acanthosis nigricans and diabetes mellitus.

Original languageEnglish
Pages (from-to)332-334
Number of pages3
JournalArchives of Disease in Childhood
Issue number4
Publication statusPublished - 1 Apr 2003
Externally publishedYes


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