Hyperkinesis and diet. A double-blind crossover trial with a tartrazine challenge

F. Levy, S. Dumbrell, G. Hobbes, M. Ryan, N. Wilton, J. M. Woodhill

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

A pilot study was conducted on 22 children (19 boys and 3 girls) aged between 4 and 8 yr, who were selected as hyperactive on the basis of developmental history and clinical judgement. Conners' parent-teacher ratings, objective tests of attention, standard perceptualmotor tests and subtests from the Wechsler Intelligence Scale for Children (WISC), were used as response variables. The children were tested before and after 4 wk on the elimination diet, after a tartrazine and placebo challenge, and, finally, after a 4 wk washout period on the diet. Results showed a statistically significant improvement in the mothers' ratings of the children's behavior after the first 4 wk of the diet. The improvement was maintained in a combined analysis of the initial 4 wk diet period and 4 wk washout period. This result was not substantiated by the statistical analysis of the results from objective tests. The rating scales and objective tests for the full sample did not show a statistically significant deteroriation in the children's behavior when they were challenged under double blind test conditions with the Yellow Dye No. 5, tartrazine, and the tests were conducted the day after a 2 wk challenge period. A comparison of mother ratings of behavior during challenge and placebo double blind trial and in the 24 hr preceding tests, in a subgroup of the children who, while on the diet, showed a 25% reduction of symptoms on the Conner's rating scale, indicated a significant challenge effect, with mothers reporting more symptoms during the challenge period. Dietary infringements with suspected trigger substances occurred throughout the trial.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalMedical Journal of Australia
Volume1
Issue number2
Publication statusPublished - 1978
Externally publishedYes

Fingerprint

Dive into the research topics of 'Hyperkinesis and diet. A double-blind crossover trial with a tartrazine challenge'. Together they form a unique fingerprint.

Cite this