Hypotensive but not normotensive haemorrhage increases tryptophan hydroxylase-2 mRNA in caudal midline medulla

Heidi J. Brown, Luke A. Henderson, Kevin A. Keay*

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Severe blood loss triggers shock, a precipitous hypotension and bradycardia. The integrity of (i) neurons in the vasodepressor region of the caudal midline medulla and (ii) central 5-HT neurotransmission are critical for the expression of haemorrhagic shock. This study investigated whether progressive blood loss triggers altered synthesis of 5-HT in the vasodepressor region of the caudal midline medulla by measuring changes in relative expression levels of tryptophan hydroxylase 2 (TpH 2) mRNA, the rate-limiting enzyme in the synthesis of neuronal 5-HT. Hypotensive but not normotensive haemorrhage triggered a significant increase in TpH 2 mRNA in the vasodepressor region of the caudal midline medulla, identifying an important role for 5-HT-containing caudal midline medullary neurons in haemorrhagic shock.

Original languageEnglish
Pages (from-to)314-318
Number of pages5
JournalNeuroscience Letters
Volume398
Issue number3
DOIs
Publication statusPublished - 8 May 2006
Externally publishedYes

Keywords

  • shock
  • blood loss
  • serotonin
  • medullary raphe
  • hypotension
  • bradycardia

Fingerprint Dive into the research topics of 'Hypotensive but not normotensive haemorrhage increases tryptophan hydroxylase-2 mRNA in caudal midline medulla'. Together they form a unique fingerprint.

  • Cite this