Hypotensive but not normotensive haemorrhage increases tryptophan hydroxylase-2 mRNA in caudal midline medulla

Heidi J. Brown; Luke A. Henderson; Kevin A. Keay

doi:10.1016/j.neulet.2006.01.019

Hypotensive but not normotensive haemorrhage increases tryptophan hydroxylase-2 mRNA in caudal midline medulla

Heidi J. Brown, Luke A. Henderson, Kevin A. Keay^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Severe blood loss triggers shock, a precipitous hypotension and bradycardia. The integrity of (i) neurons in the vasodepressor region of the caudal midline medulla and (ii) central 5-HT neurotransmission are critical for the expression of haemorrhagic shock. This study investigated whether progressive blood loss triggers altered synthesis of 5-HT in the vasodepressor region of the caudal midline medulla by measuring changes in relative expression levels of tryptophan hydroxylase 2 (TpH 2) mRNA, the rate-limiting enzyme in the synthesis of neuronal 5-HT. Hypotensive but not normotensive haemorrhage triggered a significant increase in TpH 2 mRNA in the vasodepressor region of the caudal midline medulla, identifying an important role for 5-HT-containing caudal midline medullary neurons in haemorrhagic shock.

Original language	English
Pages (from-to)	314-318
Number of pages	5
Journal	Neuroscience Letters
Volume	398
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2006.01.019
Publication status	Published - 8 May 2006
Externally published	Yes

Keywords

shock
blood loss
serotonin
medullary raphe
hypotension
bradycardia

Access to Document

10.1016/j.neulet.2006.01.019

Cite this

@article{651473204d384e24a7ffddb6382d5096,

title = "Hypotensive but not normotensive haemorrhage increases tryptophan hydroxylase-2 mRNA in caudal midline medulla",

abstract = "Severe blood loss triggers shock, a precipitous hypotension and bradycardia. The integrity of (i) neurons in the vasodepressor region of the caudal midline medulla and (ii) central 5-HT neurotransmission are critical for the expression of haemorrhagic shock. This study investigated whether progressive blood loss triggers altered synthesis of 5-HT in the vasodepressor region of the caudal midline medulla by measuring changes in relative expression levels of tryptophan hydroxylase 2 (TpH 2) mRNA, the rate-limiting enzyme in the synthesis of neuronal 5-HT. Hypotensive but not normotensive haemorrhage triggered a significant increase in TpH 2 mRNA in the vasodepressor region of the caudal midline medulla, identifying an important role for 5-HT-containing caudal midline medullary neurons in haemorrhagic shock.",

keywords = "shock, blood loss, serotonin, medullary raphe, hypotension, bradycardia",

author = "Brown, {Heidi J.} and Henderson, {Luke A.} and Keay, {Kevin A.}",

year = "2006",

month = may,

day = "8",

doi = "10.1016/j.neulet.2006.01.019",

language = "English",

volume = "398",

pages = "314--318",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Hypotensive but not normotensive haemorrhage increases tryptophan hydroxylase-2 mRNA in caudal midline medulla

AU - Brown, Heidi J.

AU - Henderson, Luke A.

AU - Keay, Kevin A.

PY - 2006/5/8

Y1 - 2006/5/8

N2 - Severe blood loss triggers shock, a precipitous hypotension and bradycardia. The integrity of (i) neurons in the vasodepressor region of the caudal midline medulla and (ii) central 5-HT neurotransmission are critical for the expression of haemorrhagic shock. This study investigated whether progressive blood loss triggers altered synthesis of 5-HT in the vasodepressor region of the caudal midline medulla by measuring changes in relative expression levels of tryptophan hydroxylase 2 (TpH 2) mRNA, the rate-limiting enzyme in the synthesis of neuronal 5-HT. Hypotensive but not normotensive haemorrhage triggered a significant increase in TpH 2 mRNA in the vasodepressor region of the caudal midline medulla, identifying an important role for 5-HT-containing caudal midline medullary neurons in haemorrhagic shock.

AB - Severe blood loss triggers shock, a precipitous hypotension and bradycardia. The integrity of (i) neurons in the vasodepressor region of the caudal midline medulla and (ii) central 5-HT neurotransmission are critical for the expression of haemorrhagic shock. This study investigated whether progressive blood loss triggers altered synthesis of 5-HT in the vasodepressor region of the caudal midline medulla by measuring changes in relative expression levels of tryptophan hydroxylase 2 (TpH 2) mRNA, the rate-limiting enzyme in the synthesis of neuronal 5-HT. Hypotensive but not normotensive haemorrhage triggered a significant increase in TpH 2 mRNA in the vasodepressor region of the caudal midline medulla, identifying an important role for 5-HT-containing caudal midline medullary neurons in haemorrhagic shock.

KW - shock

KW - blood loss

KW - serotonin

KW - medullary raphe

KW - hypotension

KW - bradycardia

UR - http://www.scopus.com/inward/record.url?scp=33646342785&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2006.01.019

DO - 10.1016/j.neulet.2006.01.019

M3 - Article

C2 - 16483717

AN - SCOPUS:33646342785

VL - 398

SP - 314

EP - 318

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -

Hypotensive but not normotensive haemorrhage increases tryptophan hydroxylase-2 mRNA in caudal midline medulla

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this