TY - JOUR
T1 - Hypothalamic mechanisms coordinating cardiorespiratory function during exercise and defensive behaviour
AU - Dampney, R. A L
AU - Horiuchi, J.
AU - McDowall, L. M.
PY - 2008/11/3
Y1 - 2008/11/3
N2 - Defensive behaviour evoked by mild or moderate psychological stress as well as increased activity and arousal are part of everyday life in humans and other animals. Both defensive behaviour and exercise are associated with marked and often quite stereotyped changes in autonomic and respiratory function. These patterned responses are generated by feed-forward or "central command" mechanisms, and are also modulated by feedback from peripheral receptors. In this review we first describe the pattern of autonomic and respiratory changes associated with defensive behaviour and exercise, and then discuss the central mechanisms that generate these patterned responses in the light of recent studies, with a particular focus on the role of the dorsomedial hypothalamus (DMH). We consider the hypothesis that the cardiorespiratory changes associated with defensive behaviour and exercise may, at least in part, be driven by common central mechanisms. Finally, we discuss the possible role of the DMH in generating circadian rhythms in arterial blood pressure and heart rate, and also in generating longer-term increases in sympathetic activity in some types of hypertension.
AB - Defensive behaviour evoked by mild or moderate psychological stress as well as increased activity and arousal are part of everyday life in humans and other animals. Both defensive behaviour and exercise are associated with marked and often quite stereotyped changes in autonomic and respiratory function. These patterned responses are generated by feed-forward or "central command" mechanisms, and are also modulated by feedback from peripheral receptors. In this review we first describe the pattern of autonomic and respiratory changes associated with defensive behaviour and exercise, and then discuss the central mechanisms that generate these patterned responses in the light of recent studies, with a particular focus on the role of the dorsomedial hypothalamus (DMH). We consider the hypothesis that the cardiorespiratory changes associated with defensive behaviour and exercise may, at least in part, be driven by common central mechanisms. Finally, we discuss the possible role of the DMH in generating circadian rhythms in arterial blood pressure and heart rate, and also in generating longer-term increases in sympathetic activity in some types of hypertension.
KW - Cardiovascular control
KW - Exercise
KW - Hypothalamus
KW - Respiratory control
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=53049084024&partnerID=8YFLogxK
U2 - 10.1016/j.autneu.2008.07.005
DO - 10.1016/j.autneu.2008.07.005
M3 - Review article
C2 - 18725186
AN - SCOPUS:53049084024
VL - 142
SP - 3
EP - 10
JO - Autonomic Neuroscience: Basic and Clinical
JF - Autonomic Neuroscience: Basic and Clinical
SN - 1566-0702
IS - 1-2
ER -