Hypothesis: A damaging role in aging for reactive protein oxidation products?

Roger T. Dean, Janusz Gebicki, Steven Gieseg, Adrienne J. Grant, Jeremy A. Simpson

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

This paper discusses our knowledge of protein oxidation and its relationship to aging. It also outlines new observations from our laboratories concerning reactive species produced during protein oxidation, and proposes that these may inflict damage on other molecules, and hence contribute to the progression of aging. Whereas it has previously been difficult to see how relatively inert protein oxidation products could possibly have any causal role in aging, the detection of these novel reactive species implies a potentially significant role.

Original languageEnglish
Pages (from-to)387-393
Number of pages7
JournalMutation Research DNAging
Volume275
Issue number3-6
DOIs
Publication statusPublished - 1992

Keywords

  • Protein-bound reactive species
  • Proteins
  • Radical damage

Fingerprint

Dive into the research topics of 'Hypothesis: A damaging role in aging for reactive protein oxidation products?'. Together they form a unique fingerprint.

Cite this