Hypothesis: A damaging role in aging for reactive protein oxidation products?

Roger T. Dean; Janusz Gebicki; Steven Gieseg; Adrienne J. Grant; Jeremy A. Simpson

doi:10.1016/0921-8734(92)90041-M

Hypothesis: A damaging role in aging for reactive protein oxidation products?

Roger T. Dean, Janusz Gebicki, Steven Gieseg, Adrienne J. Grant, Jeremy A. Simpson

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

This paper discusses our knowledge of protein oxidation and its relationship to aging. It also outlines new observations from our laboratories concerning reactive species produced during protein oxidation, and proposes that these may inflict damage on other molecules, and hence contribute to the progression of aging. Whereas it has previously been difficult to see how relatively inert protein oxidation products could possibly have any causal role in aging, the detection of these novel reactive species implies a potentially significant role.

Original language	English
Pages (from-to)	387-393
Number of pages	7
Journal	Mutation Research DNAging
Volume	275
Issue number	3-6
DOIs	https://doi.org/10.1016/0921-8734(92)90041-M
Publication status	Published - 1992

Keywords

Protein-bound reactive species
Proteins
Radical damage

Access to Document

10.1016/0921-8734(92)90041-M

Cite this

@article{7a7b1725ff9b458398192b8cb30bb5df,

title = "Hypothesis: A damaging role in aging for reactive protein oxidation products?",

abstract = "This paper discusses our knowledge of protein oxidation and its relationship to aging. It also outlines new observations from our laboratories concerning reactive species produced during protein oxidation, and proposes that these may inflict damage on other molecules, and hence contribute to the progression of aging. Whereas it has previously been difficult to see how relatively inert protein oxidation products could possibly have any causal role in aging, the detection of these novel reactive species implies a potentially significant role.",

keywords = "Protein-bound reactive species, Proteins, Radical damage",

author = "Dean, {Roger T.} and Janusz Gebicki and Steven Gieseg and Grant, {Adrienne J.} and Simpson, {Jeremy A.}",

year = "1992",

doi = "10.1016/0921-8734(92)90041-M",

language = "English",

volume = "275",

pages = "387--393",

journal = "Mutation Research DNAging",

issn = "0921-8734",

publisher = "Elsevier",

number = "3-6",

}

TY - JOUR

T1 - Hypothesis

T2 - A damaging role in aging for reactive protein oxidation products?

AU - Dean, Roger T.

AU - Gebicki, Janusz

AU - Gieseg, Steven

AU - Grant, Adrienne J.

AU - Simpson, Jeremy A.

PY - 1992

Y1 - 1992

N2 - This paper discusses our knowledge of protein oxidation and its relationship to aging. It also outlines new observations from our laboratories concerning reactive species produced during protein oxidation, and proposes that these may inflict damage on other molecules, and hence contribute to the progression of aging. Whereas it has previously been difficult to see how relatively inert protein oxidation products could possibly have any causal role in aging, the detection of these novel reactive species implies a potentially significant role.

AB - This paper discusses our knowledge of protein oxidation and its relationship to aging. It also outlines new observations from our laboratories concerning reactive species produced during protein oxidation, and proposes that these may inflict damage on other molecules, and hence contribute to the progression of aging. Whereas it has previously been difficult to see how relatively inert protein oxidation products could possibly have any causal role in aging, the detection of these novel reactive species implies a potentially significant role.

KW - Protein-bound reactive species

KW - Proteins

KW - Radical damage

UR - http://www.scopus.com/inward/record.url?scp=0026661030&partnerID=8YFLogxK

U2 - 10.1016/0921-8734(92)90041-M

DO - 10.1016/0921-8734(92)90041-M

M3 - Article

C2 - 1383779

AN - SCOPUS:0026661030

SN - 0921-8734

VL - 275

SP - 387

EP - 393

JO - Mutation Research DNAging

JF - Mutation Research DNAging

IS - 3-6

ER -

Hypothesis: A damaging role in aging for reactive protein oxidation products?

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this