Baccharis trimera infusion reduces macrophages activation and high-fat diet-induced metabolic disorders in mice

Thalita Vieira Nascimento Ximenes; Raquel Carvalho; Iluska Senna Bonfá; Vanessa Samúdio Santos; Luciane Candeloro; Flávio Macedo Alves; Denise Brentan Silva; Carlos Alexandre Carollo; Karine de Cássia Freitas; Saulo Euclides Silva-Filho; Mônica Cristina Toffoli-Kadri

doi:10.3390/ph15101258

Baccharis trimera infusion reduces macrophages activation and high-fat diet-induced metabolic disorders in mice

Thalita Vieira Nascimento Ximenes, Raquel Carvalho, Iluska Senna Bonfá, Vanessa Samúdio Santos, Luciane Candeloro, Flávio Macedo Alves, Denise Brentan Silva, Carlos Alexandre Carollo, Karine de Cássia Freitas, Saulo Euclides Silva-Filho, Mônica Cristina Toffoli-Kadri^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

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Abstract

The aim of this study is to evaluate the efficacy of Baccharis trimera infusion on high-fat diet-induced metabolic disorders in mice and macrophages activation. This study evaluated obesity, insulin resistance, dyslipidemia and hepatic steatosis induced by a high-fat diet in Swiss mice. Cellular parameters in macrophages, such as cell viability (MTT), the production and release of nitric oxide (NO) and hydrogen peroxide (H₂O₂), cell spreading, cell adhesion and phagocytosis were determined. Our results showed that treatment with B. trimera prevented the mentioned conditions, except for the production of hydrogen peroxide. B. trimera prevented the development of obesity and associated comorbidities, as well as activation of macrophages. In conclusion, B. trimera is able to prevent obesity and metabolic disorders and macrophages activation, minimizing inflammation and validating the popular use of this plant tea.

Original language	English
Article number	1258
Pages (from-to)	1-15
Number of pages	15
Journal	Pharmaceuticals
Volume	15
Issue number	10
Early online date	13 Oct 2022
DOIs	https://doi.org/10.3390/ph15101258
Publication status	Published - Oct 2022
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

obesity
hyperlipidic diet
inflammation
Swiss mice

Access to Document

10.3390/ph15101258

Publisher version (open access)Final published version, 1.35 MBLicence: CC BY

Cite this

Ximenes, T. V. N., Carvalho, R., Bonfá, I. S., Santos, V. S., Candeloro, L., Alves, F. M., Silva, D. B., Carollo, C. A., Freitas, K. D. C., Silva-Filho, S. E., & Toffoli-Kadri, M. C. (2022). Baccharis trimera infusion reduces macrophages activation and high-fat diet-induced metabolic disorders in mice. Pharmaceuticals, 15(10), 1-15. Article 1258. https://doi.org/10.3390/ph15101258

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title = "Baccharis trimera infusion reduces macrophages activation and high-fat diet-induced metabolic disorders in mice",

abstract = "The aim of this study is to evaluate the efficacy of Baccharis trimera infusion on high-fat diet-induced metabolic disorders in mice and macrophages activation. This study evaluated obesity, insulin resistance, dyslipidemia and hepatic steatosis induced by a high-fat diet in Swiss mice. Cellular parameters in macrophages, such as cell viability (MTT), the production and release of nitric oxide (NO) and hydrogen peroxide (H2O2), cell spreading, cell adhesion and phagocytosis were determined. Our results showed that treatment with B. trimera prevented the mentioned conditions, except for the production of hydrogen peroxide. B. trimera prevented the development of obesity and associated comorbidities, as well as activation of macrophages. In conclusion, B. trimera is able to prevent obesity and metabolic disorders and macrophages activation, minimizing inflammation and validating the popular use of this plant tea.",

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author = "Ximenes, \{Thalita Vieira Nascimento\} and Raquel Carvalho and Bonf{\'a}, \{Iluska Senna\} and Santos, \{Vanessa Sam{\'u}dio\} and Luciane Candeloro and Alves, \{Fl{\'a}vio Macedo\} and Silva, \{Denise Brentan\} and Carollo, \{Carlos Alexandre\} and Freitas, \{Karine de C{\'a}ssia\} and Silva-Filho, \{Saulo Euclides\} and Toffoli-Kadri, \{M{\^o}nica Cristina\}",

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AU - Ximenes, Thalita Vieira Nascimento

AU - Carvalho, Raquel

AU - Bonfá, Iluska Senna

AU - Santos, Vanessa Samúdio

AU - Candeloro, Luciane

AU - Alves, Flávio Macedo

AU - Silva, Denise Brentan

AU - Carollo, Carlos Alexandre

AU - Freitas, Karine de Cássia

AU - Silva-Filho, Saulo Euclides

AU - Toffoli-Kadri, Mônica Cristina

N1 - Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2022/10

Y1 - 2022/10

N2 - The aim of this study is to evaluate the efficacy of Baccharis trimera infusion on high-fat diet-induced metabolic disorders in mice and macrophages activation. This study evaluated obesity, insulin resistance, dyslipidemia and hepatic steatosis induced by a high-fat diet in Swiss mice. Cellular parameters in macrophages, such as cell viability (MTT), the production and release of nitric oxide (NO) and hydrogen peroxide (H2O2), cell spreading, cell adhesion and phagocytosis were determined. Our results showed that treatment with B. trimera prevented the mentioned conditions, except for the production of hydrogen peroxide. B. trimera prevented the development of obesity and associated comorbidities, as well as activation of macrophages. In conclusion, B. trimera is able to prevent obesity and metabolic disorders and macrophages activation, minimizing inflammation and validating the popular use of this plant tea.

AB - The aim of this study is to evaluate the efficacy of Baccharis trimera infusion on high-fat diet-induced metabolic disorders in mice and macrophages activation. This study evaluated obesity, insulin resistance, dyslipidemia and hepatic steatosis induced by a high-fat diet in Swiss mice. Cellular parameters in macrophages, such as cell viability (MTT), the production and release of nitric oxide (NO) and hydrogen peroxide (H2O2), cell spreading, cell adhesion and phagocytosis were determined. Our results showed that treatment with B. trimera prevented the mentioned conditions, except for the production of hydrogen peroxide. B. trimera prevented the development of obesity and associated comorbidities, as well as activation of macrophages. In conclusion, B. trimera is able to prevent obesity and metabolic disorders and macrophages activation, minimizing inflammation and validating the popular use of this plant tea.

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Baccharis trimera infusion reduces macrophages activation and high-fat diet-induced metabolic disorders in mice

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