Bifidobacterium: host–microbiome interaction and mechanism of action in preventing common gut-microbiota-associated complications in preterm infants: a narrative review

Fatemah Sadeghpour Heravi*, Honghua Hu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)
62 Downloads (Pure)

Abstract

The development and health of infants are intertwined with the protective and regulatory functions of different microorganisms in the gut known as the gut microbiota. Preterm infants born with an imbalanced gut microbiota are at substantial risk of several diseases including inflammatory intestinal diseases, necrotizing enterocolitis, late-onset sepsis, neurodevelopmental disorders, and allergies which can potentially persist throughout adulthood. In this review, we have evaluated the role of Bifidobacterium as commonly used probiotics in the development of gut microbiota and prevention of common diseases in preterm infants which is not fully understood yet. The application of Bifidobacterium as a therapeutical approach in the re-programming of the gut microbiota in preterm infants, the mechanisms of host-microbiome interaction, and the mechanism of action of this bacterium have also been investigated, aiming to provide new insights and opportunities in microbiome-targeted interventions in personalized medicine.
Original languageEnglish
Article number709
Pages (from-to)1-49
Number of pages49
JournalNutrients
Volume15
Issue number3
DOIs
Publication statusPublished - 30 Jan 2023

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • gut microbiota
  • Bifidobacterium
  • probiotic
  • preterm infants
  • host-microbiome interaction

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