Identification and characterization of a major cell wall-associated iron-regulated envelope protein (Irep-28) in Mycobacterium tuberculosis

Veena C. Yeruva, Sridevi Duggirala, V. Lakshmi, Daniel Kolarich, Friedrich Altmann, Manjula Sritharan*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)

    Abstract

    Iron limitation and the expression of mycobactin and carboxymycobactin by Mycobacterium tuberculosis are known. Here, we report how iron regulated the coordinate expression of these two siderophores and a 28-kDa cell wall-associated iron-regulated protein (Irep-28). Irep-28 is identified as the DNA-binding HU homologue HupB protein (hupB [Rv2986c]). Antibodies to this protein were detected in sera from tuberculosis patients. The location of the protein in the cell wall makes it a potential drug target.

    Original languageEnglish
    Pages (from-to)1137-1142
    Number of pages6
    JournalClinical and Vaccine Immunology
    Volume13
    Issue number10
    DOIs
    Publication statusPublished - Oct 2006

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