Abstract
Iron limitation and the expression of mycobactin and carboxymycobactin by Mycobacterium tuberculosis are known. Here, we report how iron regulated the coordinate expression of these two siderophores and a 28-kDa cell wall-associated iron-regulated protein (Irep-28). Irep-28 is identified as the DNA-binding HU homologue HupB protein (hupB [Rv2986c]). Antibodies to this protein were detected in sera from tuberculosis patients. The location of the protein in the cell wall makes it a potential drug target.
| Original language | English |
|---|---|
| Pages (from-to) | 1137-1142 |
| Number of pages | 6 |
| Journal | Clinical and Vaccine Immunology |
| Volume | 13 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2006 |
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Yeruva, V. C., Duggirala, S., Lakshmi, V., Kolarich, D., Altmann, F., & Sritharan, M. (2006). Identification and characterization of a major cell wall-associated iron-regulated envelope protein (Irep-28) in Mycobacterium tuberculosis. Clinical and Vaccine Immunology, 13(10), 1137-1142. https://doi.org/10.1128/CVI.00125-06