Abstract
Iron limitation and the expression of mycobactin and carboxymycobactin by Mycobacterium tuberculosis are known. Here, we report how iron regulated the coordinate expression of these two siderophores and a 28-kDa cell wall-associated iron-regulated protein (Irep-28). Irep-28 is identified as the DNA-binding HU homologue HupB protein (hupB [Rv2986c]). Antibodies to this protein were detected in sera from tuberculosis patients. The location of the protein in the cell wall makes it a potential drug target.
Original language | English |
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Pages (from-to) | 1137-1142 |
Number of pages | 6 |
Journal | Clinical and Vaccine Immunology |
Volume | 13 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 2006 |