Identification and characterization of a major cell wall-associated iron-regulated envelope protein (Irep-28) in Mycobacterium tuberculosis

Veena C. Yeruva; Sridevi Duggirala; V. Lakshmi; Daniel Kolarich; Friedrich Altmann; Manjula Sritharan

doi:10.1128/CVI.00125-06

Identification and characterization of a major cell wall-associated iron-regulated envelope protein (Irep-28) in Mycobacterium tuberculosis

Veena C. Yeruva, Sridevi Duggirala, V. Lakshmi, Daniel Kolarich, Friedrich Altmann, Manjula Sritharan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Iron limitation and the expression of mycobactin and carboxymycobactin by Mycobacterium tuberculosis are known. Here, we report how iron regulated the coordinate expression of these two siderophores and a 28-kDa cell wall-associated iron-regulated protein (Irep-28). Irep-28 is identified as the DNA-binding HU homologue HupB protein (hupB [Rv2986c]). Antibodies to this protein were detected in sera from tuberculosis patients. The location of the protein in the cell wall makes it a potential drug target.

Original language	English
Pages (from-to)	1137-1142
Number of pages	6
Journal	Clinical and Vaccine Immunology
Volume	13
Issue number	10
DOIs	https://doi.org/10.1128/CVI.00125-06
Publication status	Published - Oct 2006

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AU - Duggirala, Sridevi

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AU - Kolarich, Daniel

AU - Altmann, Friedrich

AU - Sritharan, Manjula

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AB - Iron limitation and the expression of mycobactin and carboxymycobactin by Mycobacterium tuberculosis are known. Here, we report how iron regulated the coordinate expression of these two siderophores and a 28-kDa cell wall-associated iron-regulated protein (Irep-28). Irep-28 is identified as the DNA-binding HU homologue HupB protein (hupB [Rv2986c]). Antibodies to this protein were detected in sera from tuberculosis patients. The location of the protein in the cell wall makes it a potential drug target.

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Identification and characterization of a major cell wall-associated iron-regulated envelope protein (Irep-28) in Mycobacterium tuberculosis

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