Identification of a bipolar disorder susceptibility locus on chromosome 15Q

Erica Zoe McAuley, Ian P. Blair, Jan M. Fullerton, Jennifer A. Donald, Philip B. Mitchell, Peter R. Schofield

    Research output: Contribution to journalMeeting abstractpeer-review


    Bipolar disorder (BP) is a highly heritable, common, severe mood
    disorder with lifetime prevalence up to 4%. We conducted a 10 cM
    genome scan on 35 multigenerational pedigrees with 288 genotyped
    individuals and identified linkage to chromosome 15q25-26. Using a
    broad disease definition including individuals diagnosed with BPI,
    schizoaffective disorder mania type, BPII or recurrent unipolar
    depression, 130 individuals in the cohort were affected. We found a
    maximumtwo pointLODscore of 3.85 and a maximummultipointLOD
    score of 4.76 at D15S130 using 60% age-specific penetrance, the
    dominant model under broad disease definition. Markers on chromosomes
    4q, 6q, and 13q suggested linkage, in addition to a second marker
    adjacent to D15S130. The region on 15q25-26 was further investigated
    by typing 8 additional microsatellite markers, yielding significant
    scores with a maximum two point LOD score of 4.66 and a maximum
    multipoint LOD score of 5.17 at marker D15S1004. A 95% confidence
    interval calculated by the Zmax-1 method suggests a support interval
    spanning 17 cM between markers D15S979 and D15S816 (86.6-
    92.8 Mb). Haplotype analysis based on pedigree-specific, identicalby-
    descent, allele sharing supported the 95% confidence interval
    estimates. The 15q25-26 locus is supported by linkage findings from
    studies on recurrent early-onset major depressive disorder, BP with
    psychotic features and a study of schizophrenic and BP subjects,
    suggesting that the locusmight contain a gene conferring susceptibility
    to both mood and psychotic disorder.
    Original languageEnglish
    Article numberO2.3
    Pages (from-to)695-696
    Number of pages2
    JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
    Issue number7
    Publication statusPublished - 5 Oct 2006
    Event14th World Congress on Psychiatric Genetics - Cagliari, Italy
    Duration: 28 Oct 20061 Nov 2006


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