Identification of a new human lens UV filter compound

Lisa M. Taylor; J. Andrew Aquilina; Richard H. Willis; Joanne F. Jamie; Roger J W Truscott

doi:10.1016/S0014-5793(01)03102-7

Identification of a new human lens UV filter compound

Lisa M. Taylor^*, J. Andrew Aquilina, Richard H. Willis, Joanne F. Jamie, Roger J W Truscott

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A new UV filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-diglucoside, has been identified in human lenses. The structure suggests that it is a further metabolic product of the second most abundant UV filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside. Quantification studies on the new compound show that it decreases towards zero in both the nucleus and cortex as a function of age. The discovery of this novel disaccharide completes the identification of the major UV filter compounds present in the human lens.

Original language	English
Pages (from-to)	6-10
Number of pages	5
Journal	FEBS Letters
Volume	509
Issue number	1
DOIs	https://doi.org/10.1016/S0014-5793(01)03102-7
Publication status	Published - 30 Nov 2001

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title = "Identification of a new human lens UV filter compound",

abstract = "A new UV filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-diglucoside, has been identified in human lenses. The structure suggests that it is a further metabolic product of the second most abundant UV filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside. Quantification studies on the new compound show that it decreases towards zero in both the nucleus and cortex as a function of age. The discovery of this novel disaccharide completes the identification of the major UV filter compounds present in the human lens.",

author = "Taylor, {Lisa M.} and Aquilina, {J. Andrew} and Willis, {Richard H.} and Jamie, {Joanne F.} and Truscott, {Roger J W}",

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AU - Taylor, Lisa M.

AU - Aquilina, J. Andrew

AU - Willis, Richard H.

AU - Jamie, Joanne F.

AU - Truscott, Roger J W

PY - 2001/11/30

Y1 - 2001/11/30

N2 - A new UV filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-diglucoside, has been identified in human lenses. The structure suggests that it is a further metabolic product of the second most abundant UV filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside. Quantification studies on the new compound show that it decreases towards zero in both the nucleus and cortex as a function of age. The discovery of this novel disaccharide completes the identification of the major UV filter compounds present in the human lens.

AB - A new UV filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-diglucoside, has been identified in human lenses. The structure suggests that it is a further metabolic product of the second most abundant UV filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside. Quantification studies on the new compound show that it decreases towards zero in both the nucleus and cortex as a function of age. The discovery of this novel disaccharide completes the identification of the major UV filter compounds present in the human lens.

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SN - 0014-5793

VL - 509

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EP - 10

JO - FEBS Letters

JF - FEBS Letters

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Identification of a new human lens UV filter compound

Abstract

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