Identification of a new human lens UV filter compound

Lisa M. Taylor*, J. Andrew Aquilina, Richard H. Willis, Joanne F. Jamie, Roger J W Truscott

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A new UV filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-diglucoside, has been identified in human lenses. The structure suggests that it is a further metabolic product of the second most abundant UV filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside. Quantification studies on the new compound show that it decreases towards zero in both the nucleus and cortex as a function of age. The discovery of this novel disaccharide completes the identification of the major UV filter compounds present in the human lens.

Original languageEnglish
Pages (from-to)6-10
Number of pages5
JournalFEBS Letters
Volume509
Issue number1
DOIs
Publication statusPublished - 30 Nov 2001

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    Taylor, L. M., Aquilina, J. A., Willis, R. H., Jamie, J. F., & Truscott, R. J. W. (2001). Identification of a new human lens UV filter compound. FEBS Letters, 509(1), 6-10. https://doi.org/10.1016/S0014-5793(01)03102-7