Identification of different subtypes of auditory neuropathy using electrocochleography

Catherine M. McMahon*, Robert B. Patuzzi, William P. R. Gibson, Halit Sanli

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

Abstract

Currently, the physiological mechanisms underlying auditory neuropathy are unclear, and there are likely to be multiple sites of lesion. A better understanding, of the disruption in individual cases may lead to more effective management and deviceselection. Frequency-specific round-windowelectrocochleography (ECochG) waveforms were used to assess local hair cell, dendritic, and axonal currents generated within the cochlea in 15 subjects with auditory neuropathy (16 ears). These results were compared with electrically evoked auditory brainstem response (EABR) measured after cochlear implantation. The results of this study demonstrate that predominantly two patterns of ECochG waveforms can be identified: (i) a prolonged latency of the hair cell summating potential (SP) waveform With Or Without residual CAP activity and (ii) a normal latency SP, typically followed by a dendritic potential (DP). We show that seven of eight Subjects with a prolonged SP showed a normal EABR waveform, consistent with a presynaptic lesion, whereas six of seven subjects with a normal latency SP showed poor morphology or absent EABR waveforms, consistent with a postsynaptic lesion. We suggest that a presynaptic and postsynaptic type of auditory neuropathy exist, which may have implications for the fitting of cochlear implants.

Original languageEnglish
Title of host publicationNeuropathies of the auditory and vestibular eighth cranial nerves
EditorsKimitaka Kaga, Arnold Starr
Place of PublicationTokyo; Berlin
PublisherSpringer, Springer Nature
Pages21-36
Number of pages16
ISBN (Electronic)9784431094333
ISBN (Print)9784431094326
DOIs
Publication statusPublished - 2009
EventInternational Mini-Symposium on Auditory Vestibular Neuropathy (Auditory Nerve Disease) - Tokyo, Japan
Duration: 3 Mar 20073 Mar 2007

Conference

ConferenceInternational Mini-Symposium on Auditory Vestibular Neuropathy (Auditory Nerve Disease)
CountryJapan
CityTokyo
Period3/03/073/03/07

Keywords

  • Auditory neuropathy
  • Electrocochleography
  • Cochlear microphonic
  • Summating potential
  • Cochlear implantation
  • ROUND-WINDOW
  • SUMMATING POTENTIALS
  • HAIR-CELLS
  • GUINEA-PIG
  • COCHLEAR IMPLANTATION
  • OTOACOUSTIC EMISSIONS
  • INNER
  • OTOFERLIN
  • EXOCYTOSIS
  • MUTATIONS

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