Identification of superficial white matter abnormalities in Alzheimer's disease and mild cognitive impairment using diffusion tensor imaging

Bahare Bigham, Seyed Amir Zamanpour, Fariba Zemorshidi, Farzaneh Boroumand, Hoda Zare*, Alzheimer's Disease Neuroimaging Initiative

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Background: Diffusion tensor imaging (DTI) estimates the microstructural alterations of the brain, as a magnetic resonance imaging (MRI)-based neuroimaging technique. Prior DTI studies reported decreased structural integrity of the superficial white matter (SWM) in the brain diseases.

Objective: This study aimed to determine the diffusion characteristics of SWM in Alzheimer's disease (AD) and mild cognitive impairment (MCI) using tractography and region of interest (ROI) approaches.

Methods: The diffusion MRI data were downloaded from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database on 24 patients with AD, 24 with MCI, and 24 normal control (NC) subjects. DTI processing was performed using DSI Studio software. First, for ROI-based analysis, The superficial white matter was divided into right and left frontal, parietal, temporal, insula, limbic and occipital regions by the Talairach Atlas, Then, for tractography-based analysis, the tractography of each of these regions was performed with 100000 seeds. Finally, the average diffusion values were extracted from voxels within the ROIs and tracts.

Results: Both tractography and ROI analyses showed a significant difference in radial, axial and mean diffusivity values between the three groups (p < 0.05) across most of the SWM. Furthermore, The Mini-Mental State Examination was significantly correlated with radial, axial, and mean diffusivity values in parietal and temporal lobes SWM in the AD group (p < 0.05).

Conclusion: DTI provided information indicating microstructural changes in the SWM of patients with AD and MCI. Therefore, assessment of the SWM using DTI may be helpful for the clinical diagnosis of patients with AD and MCI.

Original languageEnglish
Pages (from-to)49-59
Number of pages11
JournalJournal of Alzheimer's disease reports
Volume4
Issue number1
DOIs
Publication statusPublished - 28 Feb 2020
Externally publishedYes

Bibliographical note

Copyright the Publisher and the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Alzheimer's disease
  • diffusion tensor imaging
  • mild cognitive impairment
  • superficial white matter
  • tractography

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