Identification of the cellular subpopulations infiltrating rejecting cadaver renal allografts

Bruce M. Hall*, G. A. Bishop, Annabelle Farnsworth, G. G. Duggin, J. S. Horvath, A. G R Sheil, D. J. Tiller

*Corresponding author for this work

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

In the rejection response against renal allografts, the relative importance of helper/inducer T cells mediating a delayed–type hypersensitivity response and of T cells with direct cytotoxicity has not been defined. These subpopulations were identified with commercially available monoclonal antibodies and an indirect immunoperoxidase technique in 31 renal biopsies from patients undergoing acute rejection episodes and in 9 rejected nephrectomy specimens. T lymphocytes were the predominant cell population in all biopsies and in 8 of 9 nephrectomies. The T4 helper/inducer subset was equal to, or greater than, the T8 cytotoxic/suppressor subset in 28 of the 31 biopsies and in the 8 nephrectomy specimens that had histological evidence of cellular rejection. T4 lymphocytes were found predominantly in large areas of cellular infiltrate.

Original languageEnglish
Pages (from-to)564-570
Number of pages7
JournalTransplantation
Volume37
Issue number6
Publication statusPublished - 1984
Externally publishedYes

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