Identification of the new UV filter compound cysteine-l-3-hydroxykynurenine O-β-d-glucoside in human lenses

Peter G. Hains, Jasminka Mizdrak, Isla M. Streete, Joanne F. Jamie, Roger J W Truscott*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    UV filters protect the human lens and retina from UV light-induced damage. Here, we report the identification of a new UV filter, cysteine-l-3-hydroxykynurenine O-β-d-glucoside, which is present in older normal human lenses. Its structure was confirmed by independent synthesis. It is likely this novel UV filter is formed in the lens by nucleophilic attack of cysteine on the unsaturated ketone derived from deamination of 3-hydroxykynurenine O-β-d-glucoside. Quantitation studies revealed considerable variation in normal lens levels that may be traced to the marked instability of the cysteine adduct. The novel UV filter was not detected in advanced nuclear cataract lenses. Crown

    Original languageEnglish
    Pages (from-to)5071-5076
    Number of pages6
    JournalFEBS Letters
    Volume580
    Issue number21
    DOIs
    Publication statusPublished - 18 Sep 2006

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