Identification of the new UV filter compound cysteine-l-3-hydroxykynurenine O-β-d-glucoside in human lenses

Peter G. Hains, Jasminka Mizdrak, Isla M. Streete, Joanne F. Jamie, Roger J W Truscott*

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

UV filters protect the human lens and retina from UV light-induced damage. Here, we report the identification of a new UV filter, cysteine-l-3-hydroxykynurenine O-β-d-glucoside, which is present in older normal human lenses. Its structure was confirmed by independent synthesis. It is likely this novel UV filter is formed in the lens by nucleophilic attack of cysteine on the unsaturated ketone derived from deamination of 3-hydroxykynurenine O-β-d-glucoside. Quantitation studies revealed considerable variation in normal lens levels that may be traced to the marked instability of the cysteine adduct. The novel UV filter was not detected in advanced nuclear cataract lenses. Crown

Original languageEnglish
Pages (from-to)5071-5076
Number of pages6
JournalFEBS Letters
Volume580
Issue number21
DOIs
Publication statusPublished - 18 Sep 2006

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