Traditional manufacturing industry is facing significant transformation. Fundamental to this transformation, are the challenges of a changing social, economic, political and environmental future in response to climate change, global competition and limits to finite resources. These challenges have motivated a transition towards a new sustainable trajectory. Within a range of disciplinary fields, scholars have studied and developed conceptual frameworks to explain the processes, outcomes and effectiveness of particular transitions, yet, there remains limited evidence drawing together these conceptual approaches to identify the elements and attributes essential to holistic, practical and long lasting transitions within established manufacturing regions. To address this gap, this paper introduces an interdisciplinary framework, ‘Attributes of Sustainable Transitions’, by reviewing and integrating four existing conceptual approaches (Advanced Manufacturing, Sustainability Transitions, Spatiality of Regions and Transition Regions) to identify attributes of sustainable transitions within the manufacturing industry sector. In the process, this article also focuses on regions as important spaces for transitions, an emphasis currently missing from traditional economic approaches. Examples from international and Australian case studies are used to support the conceptual analysis, paving the way for future empirical research based on Australian firms.