Identifying common genetic risk factors of diabetic neuropathies

Ini-Isabée Witzel, Herbert F. Jelinek, Kinda Khalaf, Sungmun Lee, Ahsan H. Khandoker, Habiba Alsafar

Research output: Contribution to journalArticle

35 Citations (Scopus)
39 Downloads (Pure)

Abstract

Type 2 diabetes mellitus (T2DM) is a global public health problem of epidemic proportions, with 60-70% of affected individuals suffering from associated neurovascular complications that act on multiple organ systems. The most common and clinically significant neuropathies of T2DM include uremic neuropathy, peripheral neuropathy, and cardiac autonomic neuropathy. These conditions seriously impact an individual's quality of life and significantly increase the risk of morbidity and mortality. Although advances in gene sequencing technologies have identified several genetic variants that may regulate the development and progression of T2DM, little is known about whether or not the variants are involved in disease progression and how these genetic variants are associated with diabetic neuropathy specifically. Significant missing heritability data and complex disease etiologies remain to be explained. This article is the first to provide a review of the genetic risk variants implicated in the diabetic neuropathies and to highlight potential commonalities. We thereby aim to contribute to the creation of a genetic-metabolic model that will help to elucidate the cause of diabetic neuropathies, evaluate a patient's risk profile, and ultimately facilitate preventative and targeted treatment for the individual.
Original languageEnglish
Article number88
Pages (from-to)88-1-88-18
Number of pages18
JournalFrontiers in Endocrinology
Volume6
DOIs
Publication statusPublished - 2015

Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • type 2 diabetes mellitus
  • diabetic complications
  • diabetic neuropathy
  • genetic factors
  • uremic neuropathy
  • diabetic peripheral neuropathy
  • cardiac autonomic neuropathy

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