Identifying most responsive regions in the hip using composite models

Wenjun Li*, Alain Koyama, Isra Saeed, Thomas Lang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

Abstract

To identify regions inside the hip experiencing the most significant bone loss due to long-duration spaceflight, we have employed inter-subject registration to integrate hip quantitative computed tomography (QCT) scans and constructed the pre- and post-flight composite hip models for 16 astronauts, who experienced 4-6 months of spaceflights on the International Space Station. To achieve this, we applied automatic volumetric rigid and non-rigid inter-subject registration techniques to transform the two groups of hip QCT scans into a common reference hip space. Statistical comparison of the pre- and post-flight composite models illustrated tissue regions that showed the most serious bone loss inside the proximal femur. Based on the 16 subjects, such regions also showed statistical significance in bone loss according to voxel-by-voxel t-test and False Discovery Rate (FDR) analysis. By emphasizing on such most responsive regions, we can potentially develop more sensitive bone measurement methods for detecting and analyzing bone response to environmental and other factors, such as aging and osteoporosis drug therapies.

Original languageEnglish
Title of host publication2007 4th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro - Proceedings
Pages700-703
Number of pages4
DOIs
Publication statusPublished - 27 Nov 2007
Externally publishedYes
Event2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07 - Arlington, VA, United States
Duration: 12 Apr 200715 Apr 2007

Conference

Conference2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07
CountryUnited States
CityArlington, VA
Period12/04/0715/04/07

Keywords

  • Biomedical image processing
  • Bones
  • Geriatrics
  • Image registration
  • Space technology

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