IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease

Hugo Morales-Briceño; Belinda Cruse; Alessandro F. Fois; Ming-Wei Lin; Jocelyn Jiang; Dev Banerjee; Ron Grunstein; Winny Varikatt; Michael Rodriguez; Claire Shepherd; Victor S. C. Fung

doi:10.1212/WNL.0000000000005679

IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease

Hugo Morales-Briceño, Belinda Cruse, Alessandro F. Fois, Ming-Wei Lin, Jocelyn Jiang, Dev Banerjee, Ron Grunstein, Winny Varikatt, Michael Rodriguez, Claire Shepherd, Victor S. C. Fung^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

A 49-year-old man developed cold intolerance as an isolated symptom 2 years prior to presentation. At age 48, he developed jerks in the trunk and lower limbs during the day and tapping movements in the arms during sleep. After 6 months, sleep disturbance worsened with talking and gesticulations, culminating in sleeping 1-3 hours per night with associated daytime somnolence. He developed mild slurred speech, hypersalivation, and dysphagia. He reported poor memory but was able to continue driving and working. He had been diagnosed with obstructive sleep apnea 4 years prior.

Original language	English
Pages (from-to)	1113-1115
Number of pages	3
Journal	Neurology
Volume	90
Issue number	24
DOIs	https://doi.org/10.1212/WNL.0000000000005679
Publication status	Published - 12 Jun 2018
Externally published	Yes

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title = "IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease",

abstract = "A 49-year-old man developed cold intolerance as an isolated symptom 2 years prior to presentation. At age 48, he developed jerks in the trunk and lower limbs during the day and tapping movements in the arms during sleep. After 6 months, sleep disturbance worsened with talking and gesticulations, culminating in sleeping 1-3 hours per night with associated daytime somnolence. He developed mild slurred speech, hypersalivation, and dysphagia. He reported poor memory but was able to continue driving and working. He had been diagnosed with obstructive sleep apnea 4 years prior.",

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AU - Morales-Briceño, Hugo

AU - Cruse, Belinda

AU - Fois, Alessandro F.

AU - Lin, Ming-Wei

AU - Jiang, Jocelyn

AU - Banerjee, Dev

AU - Grunstein, Ron

AU - Varikatt, Winny

AU - Rodriguez, Michael

AU - Shepherd, Claire

AU - Fung, Victor S. C.

PY - 2018/6/12

Y1 - 2018/6/12

N2 - A 49-year-old man developed cold intolerance as an isolated symptom 2 years prior to presentation. At age 48, he developed jerks in the trunk and lower limbs during the day and tapping movements in the arms during sleep. After 6 months, sleep disturbance worsened with talking and gesticulations, culminating in sleeping 1-3 hours per night with associated daytime somnolence. He developed mild slurred speech, hypersalivation, and dysphagia. He reported poor memory but was able to continue driving and working. He had been diagnosed with obstructive sleep apnea 4 years prior.

AB - A 49-year-old man developed cold intolerance as an isolated symptom 2 years prior to presentation. At age 48, he developed jerks in the trunk and lower limbs during the day and tapping movements in the arms during sleep. After 6 months, sleep disturbance worsened with talking and gesticulations, culminating in sleeping 1-3 hours per night with associated daytime somnolence. He developed mild slurred speech, hypersalivation, and dysphagia. He reported poor memory but was able to continue driving and working. He had been diagnosed with obstructive sleep apnea 4 years prior.

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SN - 0028-3878

VL - 90

SP - 1113

EP - 1115

JO - Neurology

JF - Neurology

IS - 24

ER -

IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease

Abstract

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