Ikirydinium A: a new indole alkaloid from the seeds of Hunteria umbellata (K. Schum)

Olusegun S. Ajala, Andrew M. Piggott, Fabien Plisson, Zeinab Khalil, Xiao Cong Huang, Sunday A. Adesegun, Herbert A B Coker, Robert J. Capon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Chemical investigations into samples of Hunteria umbellata (K. Schum) collected in Osun State, Nigeria, led to the discovery of a new indole alkaloid, ikirydinium A, featuring an unprecedented 3-alkylpyridinium-indole-2- carboxylate scaffold. Ikirydinium A was found to exhibit antimicrobial activity (IC50 0.6 μM) against Bacillus subtilis ATCC 6051. The involvement of a common intermediate in the biosynthesis of ikirydinium A and vinblastine is hypothesized.

Original languageEnglish
Pages (from-to)7125-7127
Number of pages3
JournalTetrahedron Letters
Issue number52
Publication statusPublished - 28 Dec 2011
Externally publishedYes


  • Hunteria umbellata
  • indole alkaloids
  • natural products chemistry
  • Nigerian medicinal plant


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