Ikirydinium A: a new indole alkaloid from the seeds of Hunteria umbellata (K. Schum)

Olusegun S. Ajala; Andrew M. Piggott; Fabien Plisson; Zeinab Khalil; Xiao Cong Huang; Sunday A. Adesegun; Herbert A B Coker; Robert J. Capon

doi:10.1016/j.tetlet.2011.10.106

Ikirydinium A: a new indole alkaloid from the seeds of Hunteria umbellata (K. Schum)

Olusegun S. Ajala, Andrew M. Piggott, Fabien Plisson, Zeinab Khalil, Xiao Cong Huang, Sunday A. Adesegun, Herbert A B Coker, Robert J. Capon^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Chemical investigations into samples of Hunteria umbellata (K. Schum) collected in Osun State, Nigeria, led to the discovery of a new indole alkaloid, ikirydinium A, featuring an unprecedented 3-alkylpyridinium-indole-2- carboxylate scaffold. Ikirydinium A was found to exhibit antimicrobial activity (IC₅₀ 0.6 μM) against Bacillus subtilis ATCC 6051. The involvement of a common intermediate in the biosynthesis of ikirydinium A and vinblastine is hypothesized.

Original language	English
Pages (from-to)	7125-7127
Number of pages	3
Journal	Tetrahedron Letters
Volume	52
Issue number	52
DOIs	https://doi.org/10.1016/j.tetlet.2011.10.106
Publication status	Published - 28 Dec 2011
Externally published	Yes

Keywords

Hunteria umbellata
indole alkaloids
natural products chemistry
Nigerian medicinal plant

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10.1016/j.tetlet.2011.10.106

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title = "Ikirydinium A: a new indole alkaloid from the seeds of Hunteria umbellata (K. Schum)",

abstract = "Chemical investigations into samples of Hunteria umbellata (K. Schum) collected in Osun State, Nigeria, led to the discovery of a new indole alkaloid, ikirydinium A, featuring an unprecedented 3-alkylpyridinium-indole-2- carboxylate scaffold. Ikirydinium A was found to exhibit antimicrobial activity (IC50 0.6 μM) against Bacillus subtilis ATCC 6051. The involvement of a common intermediate in the biosynthesis of ikirydinium A and vinblastine is hypothesized.",

keywords = "Hunteria umbellata, indole alkaloids, natural products chemistry, Nigerian medicinal plant",

author = "Ajala, \{Olusegun S.\} and Piggott, \{Andrew M.\} and Fabien Plisson and Zeinab Khalil and Huang, \{Xiao Cong\} and Adesegun, \{Sunday A.\} and Coker, \{Herbert A B\} and Capon, \{Robert J.\}",

year = "2011",

month = dec,

day = "28",

doi = "10.1016/j.tetlet.2011.10.106",

language = "English",

volume = "52",

pages = "7125--7127",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier",

number = "52",

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TY - JOUR

T1 - Ikirydinium A

T2 - a new indole alkaloid from the seeds of Hunteria umbellata (K. Schum)

AU - Ajala, Olusegun S.

AU - Piggott, Andrew M.

AU - Plisson, Fabien

AU - Khalil, Zeinab

AU - Huang, Xiao Cong

AU - Adesegun, Sunday A.

AU - Coker, Herbert A B

AU - Capon, Robert J.

PY - 2011/12/28

Y1 - 2011/12/28

N2 - Chemical investigations into samples of Hunteria umbellata (K. Schum) collected in Osun State, Nigeria, led to the discovery of a new indole alkaloid, ikirydinium A, featuring an unprecedented 3-alkylpyridinium-indole-2- carboxylate scaffold. Ikirydinium A was found to exhibit antimicrobial activity (IC50 0.6 μM) against Bacillus subtilis ATCC 6051. The involvement of a common intermediate in the biosynthesis of ikirydinium A and vinblastine is hypothesized.

AB - Chemical investigations into samples of Hunteria umbellata (K. Schum) collected in Osun State, Nigeria, led to the discovery of a new indole alkaloid, ikirydinium A, featuring an unprecedented 3-alkylpyridinium-indole-2- carboxylate scaffold. Ikirydinium A was found to exhibit antimicrobial activity (IC50 0.6 μM) against Bacillus subtilis ATCC 6051. The involvement of a common intermediate in the biosynthesis of ikirydinium A and vinblastine is hypothesized.

KW - Hunteria umbellata

KW - indole alkaloids

KW - natural products chemistry

KW - Nigerian medicinal plant

UR - https://www.scopus.com/pages/publications/82255180296

U2 - 10.1016/j.tetlet.2011.10.106

DO - 10.1016/j.tetlet.2011.10.106

M3 - Article

AN - SCOPUS:82255180296

SN - 0040-4039

VL - 52

SP - 7125

EP - 7127

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 52

ER -

Ikirydinium A: a new indole alkaloid from the seeds of Hunteria umbellata (K. Schum)

Abstract

Keywords

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