Imaging methods provide crucial understanding of the uptake and distribution processes of biodegradable ZnO doped Eu3+ nanoparticles in living organism.

Ewelina Wolska-Kornio; Jaroslaw Kaszewski; Bartlomiej Witkowski; Marek Godlewski; Paula Kielbik; Mikolaj A. Gralak; Zdzislaw Gajewski; Michal M. Godlewski

doi:10.1109/IST.2016.7738267

Imaging methods provide crucial understanding of the uptake and distribution processes of biodegradable ZnO doped Eu³⁺ nanoparticles in living organism.

Ewelina Wolska-Kornio, Jaroslaw Kaszewski, Bartlomiej Witkowski, Marek Godlewski, Paula Kielbik, Mikolaj A. Gralak, Zdzislaw Gajewski, Michal M. Godlewski

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

Abstract

Oxide nanoparticles (NPs) doped with rare-earth ions are tested for applications as nanomarkers in biology. The aim of this study was to investigate the intra-organism distribution of ZnO nanoparticles doped with europium following gastric gavage (IG) in mice. The study is an example of the innovative and comprehensive methodology in research on biodistribution of nanomaterials in the body. We used quantitative (AAS) and imaging (scanning cytometry, confocal microscope) methods of assessing the distribution of rare-earth doped ZnO nanoparticles in the living organism. Visualization of these processes in the body was possible because of high fluorescence yield of europium. Imaging methods applied in this study (scanning cytometry and confocal microscopy) seem to be crucial for understanding the uptake and distribution patterns of nanoparticles within the living organism.

Original language	English
Title of host publication	2016 IEEE International Conference on Imaging Systems and Techniques (IST)
Subtitle of host publication	Proceedings
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Pages	444-448
Number of pages	5
ISBN (Electronic)	9781509018178
ISBN (Print)	9781509018185
DOIs	https://doi.org/10.1109/IST.2016.7738267
Publication status	Published - 7 Nov 2016
Externally published	Yes
Event	2016 IEEE International Conference on Imaging Systems and Techniques, IST 2016 - Chania, Crete Island, Greece Duration: 4 Oct 2016 → 6 Oct 2016

Other

Other	2016 IEEE International Conference on Imaging Systems and Techniques, IST 2016
Country/Territory	Greece
City	Chania, Crete Island
Period	4/10/16 → 6/10/16

Keywords

biomarkers
rare earth ions
ZnO

Access to Document

10.1109/IST.2016.7738267

Cite this

Wolska-Kornio, E., Kaszewski, J., Witkowski, B., Godlewski, M., Kielbik, P., Gralak, M. A., Gajewski, Z., & Godlewski, M. M. (2016). Imaging methods provide crucial understanding of the uptake and distribution processes of biodegradable ZnO doped Eu³⁺ nanoparticles in living organism. In 2016 IEEE International Conference on Imaging Systems and Techniques (IST): Proceedings (pp. 444-448). [7738267] Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/IST.2016.7738267

Wolska-Kornio, Ewelina ; Kaszewski, Jaroslaw ; Witkowski, Bartlomiej et al. / Imaging methods provide crucial understanding of the uptake and distribution processes of biodegradable ZnO doped Eu³⁺ nanoparticles in living organism. 2016 IEEE International Conference on Imaging Systems and Techniques (IST): Proceedings. Institute of Electrical and Electronics Engineers (IEEE), 2016. pp. 444-448

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abstract = "Oxide nanoparticles (NPs) doped with rare-earth ions are tested for applications as nanomarkers in biology. The aim of this study was to investigate the intra-organism distribution of ZnO nanoparticles doped with europium following gastric gavage (IG) in mice. The study is an example of the innovative and comprehensive methodology in research on biodistribution of nanomaterials in the body. We used quantitative (AAS) and imaging (scanning cytometry, confocal microscope) methods of assessing the distribution of rare-earth doped ZnO nanoparticles in the living organism. Visualization of these processes in the body was possible because of high fluorescence yield of europium. Imaging methods applied in this study (scanning cytometry and confocal microscopy) seem to be crucial for understanding the uptake and distribution patterns of nanoparticles within the living organism.",

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author = "Ewelina Wolska-Kornio and Jaroslaw Kaszewski and Bartlomiej Witkowski and Marek Godlewski and Paula Kielbik and Gralak, {Mikolaj A.} and Zdzislaw Gajewski and Godlewski, {Michal M.}",

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Wolska-Kornio, E, Kaszewski, J, Witkowski, B, Godlewski, M, Kielbik, P, Gralak, MA, Gajewski, Z & Godlewski, MM 2016, Imaging methods provide crucial understanding of the uptake and distribution processes of biodegradable ZnO doped Eu³⁺ nanoparticles in living organism. in 2016 IEEE International Conference on Imaging Systems and Techniques (IST): Proceedings., 7738267, Institute of Electrical and Electronics Engineers (IEEE), pp. 444-448, 2016 IEEE International Conference on Imaging Systems and Techniques, IST 2016, Chania, Crete Island, Greece, 4/10/16. https://doi.org/10.1109/IST.2016.7738267

Imaging methods provide crucial understanding of the uptake and distribution processes of biodegradable ZnO doped Eu³⁺ nanoparticles in living organism. / Wolska-Kornio, Ewelina; Kaszewski, Jaroslaw; Witkowski, Bartlomiej et al.
2016 IEEE International Conference on Imaging Systems and Techniques (IST): Proceedings. Institute of Electrical and Electronics Engineers (IEEE), 2016. p. 444-448 7738267.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

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Wolska-Kornio E, Kaszewski J, Witkowski B, Godlewski M, Kielbik P, Gralak MA et al. Imaging methods provide crucial understanding of the uptake and distribution processes of biodegradable ZnO doped Eu³⁺ nanoparticles in living organism. In 2016 IEEE International Conference on Imaging Systems and Techniques (IST): Proceedings. Institute of Electrical and Electronics Engineers (IEEE). 2016. p. 444-448. 7738267 doi: 10.1109/IST.2016.7738267