Imaging methods provide crucial understanding of the uptake and distribution processes of biodegradable ZnO doped Eu3+ nanoparticles in living organism.

Ewelina Wolska-Kornio, Jaroslaw Kaszewski, Bartlomiej Witkowski, Marek Godlewski, Paula Kielbik, Mikolaj A. Gralak, Zdzislaw Gajewski, Michal M. Godlewski

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

Abstract

Oxide nanoparticles (NPs) doped with rare-earth ions are tested for applications as nanomarkers in biology. The aim of this study was to investigate the intra-organism distribution of ZnO nanoparticles doped with europium following gastric gavage (IG) in mice. The study is an example of the innovative and comprehensive methodology in research on biodistribution of nanomaterials in the body. We used quantitative (AAS) and imaging (scanning cytometry, confocal microscope) methods of assessing the distribution of rare-earth doped ZnO nanoparticles in the living organism. Visualization of these processes in the body was possible because of high fluorescence yield of europium. Imaging methods applied in this study (scanning cytometry and confocal microscopy) seem to be crucial for understanding the uptake and distribution patterns of nanoparticles within the living organism.

Original languageEnglish
Title of host publication2016 IEEE International Conference on Imaging Systems and Techniques (IST)
Subtitle of host publicationProceedings
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages444-448
Number of pages5
ISBN (Electronic)9781509018178
ISBN (Print)9781509018185
DOIs
Publication statusPublished - 7 Nov 2016
Externally publishedYes
Event2016 IEEE International Conference on Imaging Systems and Techniques, IST 2016 - Chania, Crete Island, Greece
Duration: 4 Oct 20166 Oct 2016

Other

Other2016 IEEE International Conference on Imaging Systems and Techniques, IST 2016
CountryGreece
CityChania, Crete Island
Period4/10/166/10/16

Keywords

  • biomarkers
  • rare earth ions
  • ZnO

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