Immune proteins in peripheral tissue fluid-lymph in patients with filarial lymphedema of the lower limbs

W. L. Olszewski*, S. Jamal, B. Lukomska, G. Manokaran, I. Grzelak

*Corresponding author for this work

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Immune proteins and cytokine concentrations and activity were measured in skin tissue fluid-lymph and blood serum of patients with lower leg filarial lymphedema. High levels of lymph γ-globulins, α-1-acid glycoprotein and IgG lymph/serum ratio were found. Lymph from filarial patients had an elevated lymph stimulatory effect on blood mononuclear cell culture with phytohemagglutinin. There was also a high concentration and activity of IL- 1β but γ-interferon was not detected. The deranged pattern of immune proteins and high activity of IL-1 suggest persistence of an ongoing local inflammatory process despite the absence of overt dermatitis. The high tissue-lymph IL-1 concentration and activity may signify a cytokine network promoting keratinocyte and fibroblast proliferation commonly seen on skin histology in patients with filariasis.

Original languageEnglish
Pages (from-to)166-171
Number of pages6
JournalLymphology
Volume25
Issue number4
Publication statusPublished - 1992
Externally publishedYes

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