Immunocytochemical studies of neurotrophins in cerebral motor cortex in Amyotrophic Lateral Sclerosis

R. M. Duberley, I. P. Johnson*, P. Anand, P. N. Leigh, N. J. Cairns

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Neurotrophin-like immunoreactivity was studied in post-mortem motor cerebral cortex from patients with Amyotrophic Lateral Sclerosis (ALS) and controls. Neurotrophin-4/5 immunoreactivity was seen in small-(12-25 μm), medium-(26-39 μm), and large (>40 μm), neurones, neurotrophin-3 was seen in medium and small neurones, while brain-derived neurotrophic factor was restricted to small neurones. No difference in number or intensity of immunostained neurones was found between ALS and controls.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalBrain Research
Volume763
Issue number2
DOIs
Publication statusPublished - 25 Jul 1997
Externally publishedYes

Keywords

  • Amyotrophic lateral sclerosis
  • Immunocytochemistry
  • Motor cortex
  • Neurotrophic factor

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