Immunocytochemical studies of neurotrophins in cerebral motor cortex in Amyotrophic Lateral Sclerosis

R. M. Duberley; I. P. Johnson; P. Anand; P. N. Leigh; N. J. Cairns

doi:10.1016/S0006-8993(97)00465-4

Immunocytochemical studies of neurotrophins in cerebral motor cortex in Amyotrophic Lateral Sclerosis

R. M. Duberley, I. P. Johnson^*, P. Anand, P. N. Leigh, N. J. Cairns

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Neurotrophin-like immunoreactivity was studied in post-mortem motor cerebral cortex from patients with Amyotrophic Lateral Sclerosis (ALS) and controls. Neurotrophin-4/5 immunoreactivity was seen in small-(12-25 μm), medium-(26-39 μm), and large (>40 μm), neurones, neurotrophin-3 was seen in medium and small neurones, while brain-derived neurotrophic factor was restricted to small neurones. No difference in number or intensity of immunostained neurones was found between ALS and controls.

Original language	English
Pages (from-to)	259-263
Number of pages	5
Journal	Brain Research
Volume	763
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(97)00465-4
Publication status	Published - 25 Jul 1997
Externally published	Yes

Keywords

Amyotrophic lateral sclerosis
Immunocytochemistry
Motor cortex
Neurotrophic factor

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10.1016/S0006-8993(97)00465-4

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title = "Immunocytochemical studies of neurotrophins in cerebral motor cortex in Amyotrophic Lateral Sclerosis",

abstract = "Neurotrophin-like immunoreactivity was studied in post-mortem motor cerebral cortex from patients with Amyotrophic Lateral Sclerosis (ALS) and controls. Neurotrophin-4/5 immunoreactivity was seen in small-(12-25 μm), medium-(26-39 μm), and large (>40 μm), neurones, neurotrophin-3 was seen in medium and small neurones, while brain-derived neurotrophic factor was restricted to small neurones. No difference in number or intensity of immunostained neurones was found between ALS and controls.",

keywords = "Amyotrophic lateral sclerosis, Immunocytochemistry, Motor cortex, Neurotrophic factor",

author = "Duberley, {R. M.} and Johnson, {I. P.} and P. Anand and Leigh, {P. N.} and Cairns, {N. J.}",

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doi = "10.1016/S0006-8993(97)00465-4",

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AU - Duberley, R. M.

AU - Johnson, I. P.

AU - Anand, P.

AU - Leigh, P. N.

AU - Cairns, N. J.

PY - 1997/7/25

Y1 - 1997/7/25

N2 - Neurotrophin-like immunoreactivity was studied in post-mortem motor cerebral cortex from patients with Amyotrophic Lateral Sclerosis (ALS) and controls. Neurotrophin-4/5 immunoreactivity was seen in small-(12-25 μm), medium-(26-39 μm), and large (>40 μm), neurones, neurotrophin-3 was seen in medium and small neurones, while brain-derived neurotrophic factor was restricted to small neurones. No difference in number or intensity of immunostained neurones was found between ALS and controls.

AB - Neurotrophin-like immunoreactivity was studied in post-mortem motor cerebral cortex from patients with Amyotrophic Lateral Sclerosis (ALS) and controls. Neurotrophin-4/5 immunoreactivity was seen in small-(12-25 μm), medium-(26-39 μm), and large (>40 μm), neurones, neurotrophin-3 was seen in medium and small neurones, while brain-derived neurotrophic factor was restricted to small neurones. No difference in number or intensity of immunostained neurones was found between ALS and controls.

KW - Amyotrophic lateral sclerosis

KW - Immunocytochemistry

KW - Motor cortex

KW - Neurotrophic factor

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AN - SCOPUS:0030836474

SN - 0006-8993

VL - 763

SP - 259

EP - 263

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Immunocytochemical studies of neurotrophins in cerebral motor cortex in Amyotrophic Lateral Sclerosis

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Keywords

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