Immunohistochemistry in screening for heritable colorectal cancer

what to do with an abnormal result

Steven R. Paredes*, Charles Chan, Matthew J. F. X. Rickard

*Corresponding author for this work

Research output: Contribution to journalReview article


Recent developments in our understanding of molecular genetics have transformed screening and diagnostic practices for Lynch syndrome. The current standard involves universal tumour analysis of resected colorectal cancer (and ideally polypectomy) specimens using immunohistochemistry and molecular techniques. Patients with abnormal immunohistochemical findings are subsequently referred for definitive mutational testing. This review relates the molecular pathogenesis of Lynch syndrome to current immunohistochemistry-based screening strategies and discusses the interpretation and clinical implications of screening results.

Original languageEnglish
Pages (from-to)702-707
Number of pages6
JournalANZ Journal of Surgery
Issue number5
Publication statusPublished - 1 May 2020


  • cancer screening
  • colorectal cancer
  • colorectal surgery
  • hereditary cancer
  • immunohistochemistry
  • Lynch syndrome

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