Immunomodulatory properties of mesenchymal stem cells: A review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

Alan Tyndall; Ulrich A. Walker; Andrew Cope; Francesco Dazzi; Cosimo De Bari; Willem Fibbe; Serena Guiducci; Simon Jones; Christian Jorgensen; Katarina Le Blanc; Frank Luyten; Dennis McGonagle; Ivan Martin; Chiara Bocelli-Tyndall; Giuseppina Pennesi; Vito Pistoia; Constantino Pitzalis; Antonio Uccelli; Nico Wulffraat; Marc Feldmann

doi:10.1186/ar2103

Immunomodulatory properties of mesenchymal stem cells: A review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

Alan Tyndall^*, Ulrich A. Walker, Andrew Cope, Francesco Dazzi, Cosimo De Bari, Willem Fibbe, Serena Guiducci, Simon Jones, Christian Jorgensen, Katarina Le Blanc, Frank Luyten, Dennis McGonagle, Ivan Martin, Chiara Bocelli-Tyndall, Giuseppina Pennesi, Vito Pistoia, Constantino Pitzalis, Antonio Uccelli, Nico Wulffraat, Marc Feldmann

^*Corresponding author for this work

Faculty of Medicine, Health and Human Sciences

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166 Citations (Scopus)

Abstract

Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines - an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts.

Original language	English
Pages (from-to)	301-310
Number of pages	10
Journal	Arthritis Research and Therapy
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/ar2103
Publication status	Published - 29 Jan 2007

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Tyndall, A., Walker, U. A., Cope, A., Dazzi, F., De Bari, C., Fibbe, W., Guiducci, S., Jones, S., Jorgensen, C., Le Blanc, K., Luyten, F., McGonagle, D., Martin, I., Bocelli-Tyndall, C., Pennesi, G., Pistoia, V., Pitzalis, C., Uccelli, A., Wulffraat, N., & Feldmann, M. (2007). Immunomodulatory properties of mesenchymal stem cells: A review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005. Arthritis Research and Therapy, 9(1), 301-310. https://doi.org/10.1186/ar2103

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title = "Immunomodulatory properties of mesenchymal stem cells: A review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005",

abstract = "Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines - an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts. ",

author = "Alan Tyndall and Walker, \{Ulrich A.\} and Andrew Cope and Francesco Dazzi and \{De Bari\}, Cosimo and Willem Fibbe and Serena Guiducci and Simon Jones and Christian Jorgensen and \{Le Blanc\}, Katarina and Frank Luyten and Dennis McGonagle and Ivan Martin and Chiara Bocelli-Tyndall and Giuseppina Pennesi and Vito Pistoia and Constantino Pitzalis and Antonio Uccelli and Nico Wulffraat and Marc Feldmann",

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Tyndall, A, Walker, UA, Cope, A, Dazzi, F, De Bari, C, Fibbe, W, Guiducci, S, Jones, S, Jorgensen, C, Le Blanc, K, Luyten, F, McGonagle, D, Martin, I, Bocelli-Tyndall, C, Pennesi, G, Pistoia, V, Pitzalis, C, Uccelli, A, Wulffraat, N & Feldmann, M 2007, 'Immunomodulatory properties of mesenchymal stem cells: A review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005', Arthritis Research and Therapy, vol. 9, no. 1, pp. 301-310. https://doi.org/10.1186/ar2103

Immunomodulatory properties of mesenchymal stem cells: A review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005. / Tyndall, Alan; Walker, Ulrich A.; Cope, Andrew et al.
In: Arthritis Research and Therapy, Vol. 9, No. 1, 29.01.2007, p. 301-310.

Research output: Contribution to journal › Article › peer-review

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T1 - Immunomodulatory properties of mesenchymal stem cells

T2 - A review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

AU - Tyndall, Alan

AU - Walker, Ulrich A.

AU - Cope, Andrew

AU - Dazzi, Francesco

AU - De Bari, Cosimo

AU - Fibbe, Willem

AU - Guiducci, Serena

AU - Jones, Simon

AU - Jorgensen, Christian

AU - Le Blanc, Katarina

AU - Luyten, Frank

AU - McGonagle, Dennis

AU - Martin, Ivan

AU - Bocelli-Tyndall, Chiara

AU - Pennesi, Giuseppina

AU - Pistoia, Vito

AU - Pitzalis, Constantino

AU - Uccelli, Antonio

AU - Wulffraat, Nico

AU - Feldmann, Marc

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Immunomodulatory properties of mesenchymal stem cells: A review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

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