Immunoproteomic approach to elucidating the pathogenesis of cryptococcosis caused by cryptococcus gattii

Sarah E. Jobbins, Cameron J. Hill, Jocelyn M. D'Souza-Basseal, Matthew P. Padula, Ben R. Herbert, Mark B. Krockenberger

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Cryptococcosis caused by Cryptococcus gattii is a devastating disease of immunocompetent hosts with an incompletely understood pathogenesis. Utilizing an immunoproteomic approach in a naturally occurring koala model of disease, a number of key proteins and pathways are identified in the early and late pathogenesis of cryptococcosis for the first time. In particular, the thioredoxin system appears important in the pathogenesis of cryptococcosis caused by C. gattii VGII.

Original languageEnglish
Pages (from-to)3832-3841
Number of pages10
JournalJournal of Proteome Research
Volume9
Issue number8
DOIs
Publication statusPublished - 6 Aug 2010

Fingerprint Dive into the research topics of 'Immunoproteomic approach to elucidating the pathogenesis of cryptococcosis caused by cryptococcus gattii'. Together they form a unique fingerprint.

  • Cite this

    Jobbins, S. E., Hill, C. J., D'Souza-Basseal, J. M., Padula, M. P., Herbert, B. R., & Krockenberger, M. B. (2010). Immunoproteomic approach to elucidating the pathogenesis of cryptococcosis caused by cryptococcus gattii. Journal of Proteome Research, 9(8), 3832-3841. https://doi.org/10.1021/pr100028t