Immunosuppressive glycoforms of soluble CD52

Leonard Charles Harrison; Esther Bandala-Sanchez; Ethan David Goddard-Borger; Nicolle Hannah Packer; Shathili Abdulrahman Mansour

Immunosuppressive glycoforms of soluble CD52

Leonard Charles Harrison (Inventor), Esther Bandala-Sanchez (Inventor), Ethan David Goddard-Borger (Inventor), Nicolle Hannah Packer (Inventor), Shathili Abdulrahman Mansour (Inventor)

Research output: Patent

Abstract

The present disclosure relates to glycoprotein CD52 and fusion proteins thereof, wherein the CD52 glycoprotein has a-2,3-sialylated N-glycans, 0-glycosylation and a pl 5 of about 5 to about 6. The disclosure further relates to the preparation and purification of these proteins and their use in the suppression of effector T-cell function and/or immune response, such as in the treatment of diseases or conditions mediated by effector T-cell function.

Original language	English
Patent number	AU2019201584
IPC	C07K 4/12,A61K 38/00,A61K 38/10,A61K 39/00,A61P 29/00,A61P 37/00
Priority date	7/03/19
Filing date	7/03/19
Publication status	Published - 19 Mar 2020

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title = "Immunosuppressive glycoforms of soluble CD52",

abstract = "The present disclosure relates to glycoprotein CD52 and fusion proteins thereof, wherein the CD52 glycoprotein has a-2,3-sialylated N-glycans, 0-glycosylation and a pl 5 of about 5 to about 6. The disclosure further relates to the preparation and purification of these proteins and their use in the suppression of effector T-cell function and/or immune response, such as in the treatment of diseases or conditions mediated by effector T-cell function.",

author = "Harrison, {Leonard Charles} and Esther Bandala-Sanchez and Goddard-Borger, {Ethan David} and Packer, {Nicolle Hannah} and Mansour, {Shathili Abdulrahman}",

year = "2020",

month = mar,

day = "19",

language = "English",

type = "Patent",

note = "AU2019201584; C07K 4/12,A61K 38/00,A61K 38/10,A61K 39/00,A61P 29/00,A61P 37/00",

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TY - PAT

T1 - Immunosuppressive glycoforms of soluble CD52

AU - Harrison, Leonard Charles

AU - Bandala-Sanchez, Esther

AU - Goddard-Borger, Ethan David

AU - Packer, Nicolle Hannah

AU - Mansour, Shathili Abdulrahman

PY - 2020/3/19

Y1 - 2020/3/19

N2 - The present disclosure relates to glycoprotein CD52 and fusion proteins thereof, wherein the CD52 glycoprotein has a-2,3-sialylated N-glycans, 0-glycosylation and a pl 5 of about 5 to about 6. The disclosure further relates to the preparation and purification of these proteins and their use in the suppression of effector T-cell function and/or immune response, such as in the treatment of diseases or conditions mediated by effector T-cell function.

AB - The present disclosure relates to glycoprotein CD52 and fusion proteins thereof, wherein the CD52 glycoprotein has a-2,3-sialylated N-glycans, 0-glycosylation and a pl 5 of about 5 to about 6. The disclosure further relates to the preparation and purification of these proteins and their use in the suppression of effector T-cell function and/or immune response, such as in the treatment of diseases or conditions mediated by effector T-cell function.

M3 - Patent

M1 - AU2019201584

Y2 - 2019/03/07

ER -

Immunosuppressive glycoforms of soluble CD52

Abstract

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