Immunosuppressive glycoforms of soluble CD52

Leonard Charles Harrison (Inventor), Esther Bandala-Sanchez (Inventor), Ethan David Goddard-Borger (Inventor), Nicolle Hannah Packer (Inventor), Shathili Abdulrahman Mansour (Inventor)

Research output: Patent

Abstract

The present disclosure relates to glycoprotein CD52 and fusion proteins thereof, wherein the CD52 glycoprotein has a-2,3-sialylated N-glycans, 0-glycosylation and a pl 5 of about 5 to about 6. The disclosure further relates to the preparation and purification of these proteins and their use in the suppression of effector T-cell function and/or immune response, such as in the treatment of diseases or conditions mediated by effector T-cell function.

Original languageEnglish
Patent numberAU2019201584
IPCC07K 4/12,A61K 38/00,A61K 38/10,A61K 39/00,A61P 29/00,A61P 37/00
Priority date7/03/19
Filing date7/03/19
Publication statusPublished - 19 Mar 2020

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