Impact of MRI protocols on Alzheimer's disease detection

Saruar Alam, Len Hamey, Kevin Ho-Shon

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review


Alzheimer's disease (AD) can be detected using magnetic resonance imaging (MRI) based features and supervised classifiers. The subcortical and ventricular volumes change for AD patients. These volumes can be extracted from MRI by tools such as FreeSurfer and the multi-atlas-based likelihood fusion (MALF) algorithm. Studies use MRI from many medical imaging centers. However, individual centers typically use distinctive MRI protocols for brain scanning. The protocol differences include different scanner models with various operating parameters. Some scanner models have different field strengths. A key factor in classifying multicentric MR subject images having different protocols is how different scanner models affect the extraction of feature, and the subsequent classification performance of a supervised classifier. We have investigated the classification performance of FreeSurfer and MALF based volume features together with Radial Basis Function Support Vector Machine and Extreme Learning Machine across different imaging protocols. We have also investigated for both FreeSurfer and MALF, which brain regions are most effective for the detection of the disease under different protocols. Our study result indicates marginal differences in classification performance across scanner models with the same or different field strengths when differentiating AD, Mild Cognitive Impairment, and Normal Controls. We have also observed differences in ranking order of the most effective brain regions.

Original languageEnglish
Title of host publication2018 International Conference on Digital Image Computing
Subtitle of host publicationTechniques and Applications, DICTA 2018
EditorsManzur Murshed, Manoranjan Paul, Md Asikuzzaman, Mark Pickering, Ambarish Natu, Antonio Robles-Kelly, Shaodi You, Lihong Zheng, Ashfaqur Rahman
Place of PublicationPiscataway, NJ
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Number of pages8
ISBN (Electronic)9781538666029
ISBN (Print)9781538666036
Publication statusPublished - 16 Jan 2019
Event2018 International Conference on Digital Image Computing: Techniques and Applications, DICTA 2018 - Canberra, Australia
Duration: 10 Dec 201813 Dec 2018


Conference2018 International Conference on Digital Image Computing: Techniques and Applications, DICTA 2018


  • AD
  • CN
  • FreeSurfer
  • MALF
  • MCI
  • ROI


Dive into the research topics of 'Impact of MRI protocols on Alzheimer's disease detection'. Together they form a unique fingerprint.

Cite this