Impact of thrombus aspiration use for the treatment of stent thrombosis on early patient outcomes

Gilles Lemesle, Axel De Labriolle, Laurent Bonello, Tina L. Pinto Slottow, Rebecca Torguson, Kimberly Kaneshige, Daniel H. Steinberg, Probal Roy, Zhenyi Xue, William O. Suddath, Lowell F. Satler, Kenneth M. Kent, Joseph Lindsay, Augusto D. Pichard, Ron Waksman*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    BACKGROUND: Recent data suggest a clinical benefit with the systematic use of thrombus aspiration (TA) for the treatment of STelevation myocardial infarction (STEMI). Nevertheless, the impact of TA as a treatment strategy for stent thrombosis (ST) is unknown. This study aimed to analyze the impact of TA use for the treatment of ST on patient outcomes. METHODS: From 2003 to 2008, 91 consecutive patients who presented with a definite ST were included in this analysis. We compared procedural success rates and the incidence of the composite criteria deathrecurrent MI-recurrent ST at 30 days in patients who were treated with TA (TA group, n ≤ 36) versus those who were not (No-TA group, n ≤ 55). RESULTS: Baseline characteristics were similar between the two groups except for the body mass index: 26.2 ± 5.4 vs. 29.3 ± 6.2 in the TA and No- TA groups, respectively (p ≤ 0.028). ST presented more likely as STEMI in the TA group: 86.1 vs. 67.3 (p ≤ 0.043). Except for TA use, there was no difference in the treatment therapeutics between groups, including for glycoprotein IIb/IIIa inhibitors. The rate of procedural success was higher in the TA group than in the No-TA group: 88.9 vs. 70.9 (p ≤ 0.043). The incidence of the endpoint of death-recurrent MI-recurrent ST was significantly lower in the TA group: 22.2 vs. 47.2 (p ≤ 0.026). By multivariate analysis, TA use was independently associated with a decrease in the composite criteria (HR ≤ 0.45, p ≤ 0.039). CONCLUSION: This study suggests that TA use for ST treatment permits an improvement in patient outcomes at 30 days with a significant decrease in the incidence of the composite criteria death-recurrent MI-recurrent ST. Further prospective studies are needed, however, to definitively address the benefit of TA use in this particular setting.

    Original languageEnglish
    Pages (from-to)210-214
    Number of pages5
    JournalJournal of Invasive Cardiology
    Volume21
    Issue number5
    Publication statusPublished - May 2009

    Keywords

    • Myocardial infarction
    • Percutaneous coronary intervention
    • Stent thrombosis
    • Thrombus aspiration

    Fingerprint Dive into the research topics of 'Impact of thrombus aspiration use for the treatment of stent thrombosis on early patient outcomes'. Together they form a unique fingerprint.

    Cite this