Impaired fear extinction in adolescent rodents

behavioural and neural analyses

Kathryn D. Baker*, Madelyne A. Bisby, Rick Richardson

*Corresponding author for this work

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Despite adolescence being a developmental window of vulnerability, up until very recently there were surprisingly few studies on fear extinction during this period. Here we summarise the recent work in this area, focusing on the unique behavioural and neural characteristics of fear extinction in adolescent rodents, and humans where relevant. A prominent hypothesis posits that anxiety disorders peak during late childhood/adolescence due to the non-linear maturation of the fear inhibition neural circuitry. We discuss evidence that impaired extinction retention in adolescence is due to subregions of the medial prefrontal cortex and amygdala mediating fear inhibition being underactive while other subregions that mediate fear expression are overactive. We also review work on various interventions and surprising circumstances which enhance fear extinction in adolescence. This latter work revealed that the neural correlates of extinction in adolescence are different to that in younger and older animals even when extinction retention is not impaired. This growing body of work highlights that adolescence is a unique period of development for fear inhibition.

Original languageEnglish
Pages (from-to)59-73
Number of pages15
JournalNeuroscience and Biobehavioral Reviews
Volume70
DOIs
Publication statusPublished - Nov 2016
Externally publishedYes

Keywords

  • extinction
  • fear
  • adolescence
  • medial prefrontal cortex
  • amygdala

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