Improved green biosynthesis of chitosan decorated Ag- and Co3O4-nanoparticles: a relationship between surface morphology, photocatalytic and biomedical applications

Mahsa Kiani, Navid Rabiee, Mojtaba Bagherzadeh*, Amir Mohammad Ghadiri, Yousef Fatahi, Rassoul Dinarvand, Thomas J. Webster*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

AgNPs@Chitosan and Co3O4-NPs@Chitosan were fabricated with Salvia hispanica. Results showed MZI values of 5 and 30 mm for Co3O4-NPs- and AgNPs@Chitosan against S. aureus, and 15 and 21 mm for Co3O4-NPs- and AgNPs@Chitosan against E. coli (24 h, 20 μg/mL), respectively. MTT assays showed up to 80% and 90%, 71% and 75%, and 91% and 94% mammalian cell viability for the green synthesized, chemically synthesized AgNPs and green synthesized AgNPs@Chitosan for HEK-293 and PC12 cells, respectively, and 70% and 71%, 59% and 62%, and 88% and 73% for the related Co3O4-NPs (24 h, 20 μg/mL). The photocatalytic activities showed dye degradation after 135 and 105 min for AgNPs@Chitosan and Co3O4-NPs@Chitosan, respectively. FESEM results showed differences in particle sizes (32 ± 3.0 nm for the AgNPs and 41 ± 3.0 nm for the Co3O4NPs) but AFM results showed lower roughness of the AgNPs@Chitosan (7.639 ± 0.85 nm) compared to Co3O4NPs@Chitosan (9.218 ± 0.93 nm), which resulted in potential biomedical applications.

Original languageEnglish
Article number102331
Pages (from-to)1-10
Number of pages10
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume32
DOIs
Publication statusPublished - Feb 2021
Externally publishedYes

Keywords

  • Cobalt oxide nanoparticles
  • Salvia hispanica
  • Ag nanoparticles
  • Antibacterial
  • Green synthesis

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