Improved survival with elective neck dissection in thick early-stage oral squamous cell carcinoma

Ardalan Ebrahimi, Bruce G. Ashford, Jonathan R. Clark*

*Corresponding author for this work

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background Management of the node-negative neck in T1 to T2 oral squamous cell carcinoma (SCC) remains controversial. The purpose of this study was to determine if elective neck dissection improves outcomes in thick primary tumors since this reflects current practice in most institutions and has not been specifically addressed in the literature. Methods Retrospective analysis comparing elective neck dissection versus observation in 153 patients with T1 to T2 N0 oral SCC ≥4 mm thick. Results On multivariable analysis, elective neck dissection was a significant predictor of improved regional control (hazard ratio [HR], 0.1; p <.001), disease-specific (HR, 0.1; p <.001), and overall survival (HR, 0.3; p =.001). Regional failure accounted for 22% of disease-related deaths in the elective neck dissection group compared to 92% in the observation arm. Conclusion Elective neck dissection is associated with a clinically significant survival advantage in thick T1 to T2 oral SCC by reducing the risk of regional failure, and we support its routine application in these patients.

Original languageEnglish
Pages (from-to)709-716
Number of pages8
JournalHead and Neck
Volume34
Issue number5
DOIs
Publication statusPublished - May 2012
Externally publishedYes

Keywords

  • head and neck
  • lymph nodes
  • neck dissection
  • oral cancer
  • squamous cell carcinoma

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