Improvement of the omega 3 index of healthy subjects does not alter the effects of dietary saturated fats or n-6PUFA on LDL profiles

Cintia B. Dias, Núria Amigó, Lisa G. Wood, Roger Mallol, Xavier Correig, Manohar L. Garg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Background and Aims: Dietary fat composition is known to modulate circulating lipid and lipoprotein levels. Although supplementation with long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to reduce plasma triglyceride levels, the effect of the interactions between LCn-3PUFA and the major dietary fats consumed has not been previously investigated. 

Methods: In a randomized controlled parallel design clinical intervention, we examined the effect of diets rich in either saturated fatty acids (SFA) or omega-6 polyunsaturated fatty acids (n-6PUFA) on plasma lipid levels and lipoprotein profiles (lipoprotein size, concentration and distribution in subclasses) in subjects with an adequate omega 3 index. Twenty six healthy subjects went through a four-week pre-supplementation period with LCn-3PUFA and were then randomized to diets rich in either n-6PUFA or SFA both supplemented with LCn-3PUFA. 

Results: The diet rich in n-6PUFA decreased low density lipoprotein (LDL) particle concentration (−8%, p = 0.013) and LDL cholesterol (LDL-C) level (−8%, p = 0.021), while the saturated fat rich diet did not affect LDL particle concentration or LDL-C levels significantly. Nevertheless, dietary saturated fatty acids increased LCn-3PUFA in plasma and tissue lipids compared with n-6PUFA, potentially reducing other cardiovascular risk factors such as inflammation and clotting tendency. Conclusion Improvement on the omega 3 index of healthy subjects did not alter the known effects of dietary saturated fats and n-6PUFA on LDL profiles.

Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalMetabolism: Clinical and Experimental
Publication statusPublished - 1 Mar 2017
Externally publishedYes


  • Lipids
  • Lipoprotein profiles
  • Nuclear magnetic resonance spectroscopy
  • Omega-3 polyunsaturated fatty acids
  • Saturated fatty acids


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