Improving API lung permeability using hyperthermia

Larissa Gomes dos Reis, Dina M. Silva, Daniela Traini, Vitor Sencadas

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

Abstract

After an active pharmaceutical ingredient (API) is aerosolized and deposited in the lung, the API needs to be dissolved and transported across the pulmonary epithelia to exert its therapeutic effect. API permeability is considered a major drawback for achieving adequate treatment efficacy, and an important predictor of effect duration for locally-acting drugs, due to its correlation with local residence time. In the past few years, the use of hyperthermia (defined as elevated core temperature >38.5°C) has risen as a potential complementary tool to increase API permeability, and consequently for enhancing the efficacy of delivered drugs. Specifically for lung therapies, the effects of this increase in temperature has been investigated mostly for the treatment of lung cancer and restricted to increasing cytotoxicity to lung cancer cells, with no studies on drug permeability. This study aims to investigate the effect of hyperthermia on the permeability of inhaled APIs across lung epithelia.
Original languageEnglish
Title of host publicationRespiratory Drug Delivery 2020
EditorsR. N. Dalby, P. R. Byron, M. Hindle, J. Peart, D. Traini, P. M. Young, S. J. Farr, J. D. Suman, A. Watts
Place of PublicationRichmond, VA
PublisherRDD Online
Pages749-752
Number of pages4
Volume3
ISBN (Electronic)9781942911487
Publication statusPublished - 2020
Externally publishedYes
EventRespiratory Drug Delivery 2020 - Palm Desert, United States
Duration: 26 Apr 202030 Apr 2020

Conference

ConferenceRespiratory Drug Delivery 2020
CountryUnited States
CityPalm Desert
Period26/04/2030/04/20

Keywords

  • active pharmaceutical ingredient (API)
  • permeability
  • salbutamol sulphate
  • Calu-3 cells
  • hyperthermia
  • transporters

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