Improving differential diagnosis of pituitary adenomas

Luis V. Syro*, Carlos E. Builes, Antonio Di Ieva, Aydin Sav, Fabio Rotondo, Kalman Kovacs

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)


Pituitary adenomas are common tumors arising in adenohypophysial cells or their precursors. For improving control of the disease an early diagnosis is important. Initially considered sporadic tumors, some of them are associated with familial syndromes and their recognition and classification is also required. Morphologically, pituitary adenomas represent a heterogeneous group of tumors with several subtypes and different clinical behavior thus a precise pathological diagnosis is crucial. The simple diagnosis of pituitary adenoma is not satisfactory and the correct classification of histological subtypes may predict aggressiveness in the majority of cases. Although considered not malignant, some of them are clinically aggressive and their recognition remains a challenge. In this paper we present the recent advances in the event of improving early recognition and differential diagnosis of pituitary tumors.

Original languageEnglish
Pages (from-to)377-386
Number of pages10
JournalExpert Review of Endocrinology and Metabolism
Issue number4
Publication statusPublished - Jul 2014
Externally publishedYes


  • Classification
  • Diagnosis
  • Familial syndrome
  • Genetics
  • Pathology
  • Pituitary adenoma


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