Improving the accuracy of retrieved cardiac electrical conductivities

A. Kamalakkannan*, P. R. Johnston, B. M. Johnston

*Corresponding author for this work

Research output: Contribution to journalConference paperpeer-review

Abstract

Accurate values for the six cardiac conductivities of the bidomain model are crucial for meaningful electrophysiological simulations of cardiac tissue and are yet to be achieved. A two-stage optimisation process is used to retrieve the cardiac conductivities from cardiac potentials measured on a multi-electrode array—the first stage simultaneously fits all six conductivities, and the second stage fits a subset of the conductivities (intracellular conductivities), while holding the remainder of the conductivities (extracellular conductivities) constant. Previous studies have shown that the intracellular conductivities are retrieved to a lesser degree of accuracy than extracellular conductivities. This study tests the proposition that there exists a relationship between the extracellular and intracellular conductivities during the second stage of the optimisation that affects the accuracy of the retrieved intracellular conductivities. A measure to quantify this relationship is developed using polynomial chaos. The results show that a significant relationship does exist, and thus any errors in the extracellular conductivities are magnified in the retrieved intracellular conductivities. Thus, it is suggested that future protocols for retrieving conductivities incorporate the uncertainty in the extracellular conductivities.
Original languageEnglish
Pages (from-to)C154-C167
Number of pages14
JournalANZIAM Journal
Volume63
DOIs
Publication statusPublished - Aug 2022
Externally publishedYes
EventEMAC 2021: 15th Engineering Mathematics and Applications Conference - Online, Australia
Duration: 2 Dec 20213 Dec 2021

Keywords

  • Cardiac Conductivity Values
  • Computational Cardiology
  • Polynomial Chaos
  • Bidomain Model

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