TY - JOUR
T1 - In-Body network biomedical applications
T2 - from modeling to experimentation
AU - Loscr, Valeria
AU - Matekovits, Ladislau
AU - Peter, Ildiko
AU - Vegni, Anna Maria
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Innovative diagnostic approaches and therapies are more and more based on the use of injections or oral delivery of nanoparticle sized substances. For a better understanding of the overall phenomena, aiming to facilitate a safe application at large scale, the development of accurate models and analysis techniques are required. These techniques take into consideration different aspects of the overall process: Accurate numerical modeling of the different phases of the nanoparticles in the body, and knowledge of the local environment, that can be varying very fast within a short-range in the body itself. Such aspects should be taken into account to correctly predict the amount of drug and its timely release for the specific disease. Deep and accurate analysis of the interaction between the nanoparticles and the biological fluid where the nanoparticles are immersed is mandatory for an efficient correlation of all these aspects. Because of their biocompatibility, in this paper, we focus our attention on systems of Titanium (Ti), and its oxide (e.g.Tio2), given their specific features in terms of density, lack of cytotoxic effects, etc. Specifically, we present the study and design of an in-body system by characterizing each of the emission, diffusion, and reception processes with a proper realistic model. The theoretical investigation is further supported by experimental study of the morphology and other important characteristics (e.g., the pH of the particles, and thermal stability) of systems when immersed in a Ringer solution, in order to derive important information related to their potential toxicity inside the human body.
AB - Innovative diagnostic approaches and therapies are more and more based on the use of injections or oral delivery of nanoparticle sized substances. For a better understanding of the overall phenomena, aiming to facilitate a safe application at large scale, the development of accurate models and analysis techniques are required. These techniques take into consideration different aspects of the overall process: Accurate numerical modeling of the different phases of the nanoparticles in the body, and knowledge of the local environment, that can be varying very fast within a short-range in the body itself. Such aspects should be taken into account to correctly predict the amount of drug and its timely release for the specific disease. Deep and accurate analysis of the interaction between the nanoparticles and the biological fluid where the nanoparticles are immersed is mandatory for an efficient correlation of all these aspects. Because of their biocompatibility, in this paper, we focus our attention on systems of Titanium (Ti), and its oxide (e.g.Tio2), given their specific features in terms of density, lack of cytotoxic effects, etc. Specifically, we present the study and design of an in-body system by characterizing each of the emission, diffusion, and reception processes with a proper realistic model. The theoretical investigation is further supported by experimental study of the morphology and other important characteristics (e.g., the pH of the particles, and thermal stability) of systems when immersed in a Ringer solution, in order to derive important information related to their potential toxicity inside the human body.
KW - nanomedicine
KW - THz band channel capacity
KW - TiO2 particles
UR - http://www.scopus.com/inward/record.url?scp=84960118642&partnerID=8YFLogxK
U2 - 10.1109/TNB.2016.2521386
DO - 10.1109/TNB.2016.2521386
M3 - Article
C2 - 26829800
AN - SCOPUS:84960118642
SN - 1536-1241
VL - 15
SP - 53
EP - 61
JO - IEEE Transactions on Nanobioscience
JF - IEEE Transactions on Nanobioscience
IS - 1
M1 - 7390260
ER -