In vitro biosynthesis of unnatural enterocin and wailupemycin polyketides

John A. Kalaitzis, Qian Cheng, Paul M. Thomas, Neil L. Kelleher, Bradley S. Moore

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Nature has evolved finely tuned strategies to synthesize rare and complex natural products such as the enterocin family of polyketides from the marine bacterium Streptomyces maritimus. Herein we report the directed ex vivo multienzyme syntheses of 24 unnatural 5-deoxyenterocin and wailupemycin F and G analogues, 18 of which are new. We have generated molecular diversity by priming the enterocin biosynthesis enzymes with unnatural substrates and have illustrated further the uniqueness of this type II polyketide synthase by way of exploiting its unusual starter unit biosynthesis pathways.

Original languageEnglish
Pages (from-to)469-472
Number of pages4
JournalJournal of Natural Products
Issue number3
Publication statusPublished - 2009
Externally publishedYes


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