In vivo size and shape measurement of the human upper airway using endoscopie long-range optical coherence tomography

Julian J. Armstrong; Matthew S. Leigh; Ian D. Walton; Andrei V. Zvyagin; Sergey A. Alexandrov; Stefan Schwer; David D. Sampson; David R. Hillman; Peter R. Eastwood

In vivo size and shape measurement of the human upper airway using endoscopie long-range optical coherence tomography

Julian J. Armstrong^*, Matthew S. Leigh, Ian D. Walton, Andrei V. Zvyagin, Sergey A. Alexandrov, Stefan Schwer, David D. Sampson, David R. Hillman, Peter R. Eastwood

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

We describe a long-range optical coherence tomography system for size and shape measurement of large hollow organs in the human body. The system employs a frequency-domain optical delay line of a configuration that enables the combination of high-speed operation with long scan range. We compare the achievable maximum delay of several delay line configurations, and identify the configurations with the greatest delay range. We demonstrate the use of one such long-range delay line in a catheter-based optical coherence tomography system and present profiles of the human upper airway and esophagus in vivo with a radial scan range of 26 millimeters. Such quantitative upper airway profiling should prove valuable in investigating the pathophysiology of airway collapse during sleep (obstructive sleep apnea).

Original language	English
Pages (from-to)	1817-1826
Number of pages	10
Journal	Optics Express
Volume	11
Issue number	15
Publication status	Published - 2003
Externally published	Yes

Cite this

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title = "In vivo size and shape measurement of the human upper airway using endoscopie long-range optical coherence tomography",

abstract = "We describe a long-range optical coherence tomography system for size and shape measurement of large hollow organs in the human body. The system employs a frequency-domain optical delay line of a configuration that enables the combination of high-speed operation with long scan range. We compare the achievable maximum delay of several delay line configurations, and identify the configurations with the greatest delay range. We demonstrate the use of one such long-range delay line in a catheter-based optical coherence tomography system and present profiles of the human upper airway and esophagus in vivo with a radial scan range of 26 millimeters. Such quantitative upper airway profiling should prove valuable in investigating the pathophysiology of airway collapse during sleep (obstructive sleep apnea).",

author = "Armstrong, {Julian J.} and Leigh, {Matthew S.} and Walton, {Ian D.} and Zvyagin, {Andrei V.} and Alexandrov, {Sergey A.} and Stefan Schwer and Sampson, {David D.} and Hillman, {David R.} and Eastwood, {Peter R.}",

year = "2003",

language = "English",

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journal = "Optics Express",

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T1 - In vivo size and shape measurement of the human upper airway using endoscopie long-range optical coherence tomography

AU - Armstrong, Julian J.

AU - Leigh, Matthew S.

AU - Walton, Ian D.

AU - Zvyagin, Andrei V.

AU - Alexandrov, Sergey A.

AU - Schwer, Stefan

AU - Sampson, David D.

AU - Hillman, David R.

AU - Eastwood, Peter R.

PY - 2003

Y1 - 2003

N2 - We describe a long-range optical coherence tomography system for size and shape measurement of large hollow organs in the human body. The system employs a frequency-domain optical delay line of a configuration that enables the combination of high-speed operation with long scan range. We compare the achievable maximum delay of several delay line configurations, and identify the configurations with the greatest delay range. We demonstrate the use of one such long-range delay line in a catheter-based optical coherence tomography system and present profiles of the human upper airway and esophagus in vivo with a radial scan range of 26 millimeters. Such quantitative upper airway profiling should prove valuable in investigating the pathophysiology of airway collapse during sleep (obstructive sleep apnea).

AB - We describe a long-range optical coherence tomography system for size and shape measurement of large hollow organs in the human body. The system employs a frequency-domain optical delay line of a configuration that enables the combination of high-speed operation with long scan range. We compare the achievable maximum delay of several delay line configurations, and identify the configurations with the greatest delay range. We demonstrate the use of one such long-range delay line in a catheter-based optical coherence tomography system and present profiles of the human upper airway and esophagus in vivo with a radial scan range of 26 millimeters. Such quantitative upper airway profiling should prove valuable in investigating the pathophysiology of airway collapse during sleep (obstructive sleep apnea).

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AN - SCOPUS:2942735122

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JO - Optics Express

JF - Optics Express

IS - 15

ER -

In vivo size and shape measurement of the human upper airway using endoscopie long-range optical coherence tomography

Abstract

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