Incidence and determinants of myocardial infarction following percutaneous coronary interventions according to the revised Joint Task Force definition of troponin T elevation

Richard F. Alcock, Probal Roy, Katrina Adorini, George T. Lau, Len Kritharides, Harry C. Lowe, David B. Brieger, Saul Benedict Freedman*

*Corresponding author for this work

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    Background: Elevations in troponin T (TnT) occur frequently following percutaneous coronary intervention (PCI) and are associated with an adverse prognosis. The Joint ESC/ACC/AHA/WHF Task Force have released a proposal for a universal definition of myocardial infarction (MI), including diagnostic criteria for PCI associated MI. This is based on a TnT cut-point of more than three times the 99th percentile (0.03 ng/ml), which better reflects the precision of the assay. Our study investigated the incidence and predictive factors of a PCI associated MI, using the revised definition. Methods: 325 patients were studied following PCI with stenting. TnT was collected at both 8 and 18 h following PCI in patients with either stable or unstable angina and normal baseline TnT levels. Comparison was made of both clinical and procedural characteristics of patients with and without a rise in TnT following intervention, using cut points of 0.01 and 0.03 ng/ml. Results: TnT was elevated ≥ 0.03 ng/ml in 27% and ≥ 0.01 ng/ml in 39% of patients following PCI. Troponin elevation was significantly more likely in those patients who experienced peri-procedural ischemic symptoms or EKG changes, or in whom abciximab was used. The variables associated with a troponin rise showed a greater difference between TnT positive and negative patients when using 0.03 ng/ml compared to 0.01 ng/ml, suggesting that this may be a better definition of PCI-related MI. Conclusions: Approximately one-quarter of low risk patients experience a procedural MI according to the revised definition. Rises in troponin were significantly associated with peri-procedural ischemic symptoms and EKG changes, and abciximab use, consistent with this level of TnT reflecting true myocardial necrosis.

    Original languageEnglish
    Pages (from-to)66-72
    Number of pages7
    JournalInternational Journal of Cardiology
    Volume140
    Issue number1
    DOIs
    Publication statusPublished - 1 Apr 2010

    Keywords

    • Myocardial infarction
    • PCI
    • Troponin

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