Increased arterial stiffness does not respond to renal denervation in an animal model of secondary hypertension

Yimin Yao, Cara M. Hildreth, Sheran Li, Rochelle Boyd, Zahra Kouchaki, Mark Butlin, Alberto P. Avolio, Paul M. Pilowsky, Jacqueline K. Phillips

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

Abstract

Renal denervation is a novel device based therapy promoted to reduce high blood pressure. We examined the impact of renal denervation on systolic blood pressure, renal function, and arterial stiffness in the Lewis Polycystic Kidney disease (LPK) rodent model of kidney disease. Animals were subjected to bilateral renal denervation or sham surgeries at age 6 and 12 weeks. Systolic blood pressure was monitored by tail-cuff plethysmography and renal function by urinalysis and creatinine clearance. At age 16 weeks, beat-to-beat aortic pulse wave velocity as a functional indicator of arterial stiffness was determined. Renal denervation produced an overall reduction in blood pressure in the LPK [(denervated 164±4 vs. sham-operated 180±6 mmHg, n = 6 per group, P=0.003)] and delayed, but did not prevent, the decline in renal function. Aortic pulse wave velocity was markedly elevated in the LPK compared with Lewis and was not altered by renal denervation in the LPK however a reduction was seen in the control Lewis animals. These results support the hypothesis that renal nerves contribute to secondary hypertension in conditions such as kidney disease.

Original languageEnglish
Title of host publication39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2017 : proceedings
Subtitle of host publicationSmarter Technology for a Healthier World
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages258-261
Number of pages4
ISBN (Electronic)9781509028092
DOIs
Publication statusPublished - 13 Sep 2017
Event39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017 - Jeju Island, Korea, Republic of
Duration: 11 Jul 201715 Jul 2017

Conference

Conference39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
CountryKorea, Republic of
CityJeju Island
Period11/07/1715/07/17

Fingerprint Dive into the research topics of 'Increased arterial stiffness does not respond to renal denervation in an animal model of secondary hypertension'. Together they form a unique fingerprint.

Cite this