Increased Cerebral Glucose‐6‐Phosphate Dehydrogenase Activity in Alzheimer's Disease May Reflect Oxidative Stress

Ralph N. Martins*, Clive G. Harper, Gilbert B. Stokes, Colin L. Masters

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

197 Citations (Scopus)

Abstract

Abstract: The activities of the hexose monophosphate pathway enzymes glucose‐6‐phosphate dehydrogenase and 6‐phosphogluconate dehydrogenase were measured at autopsy in control and Alzheimer's disease brains. Enzyme activities did not vary between different areas of brain and were unaltered by age. In Alzheimer's disease, the activities of both enzymes were increased, the glucose‐6‐phosphate dehydrogenase activity being almost double the activity of normal controls. We propose that this increased enzyme activity is a response to elevated brain peroxide metabolism.

Original languageEnglish
Pages (from-to)1042-1045
Number of pages4
JournalJournal of Neurochemistry
Volume46
Issue number4
DOIs
Publication statusPublished - 1986
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Brain
  • Glucose‐6‐phosphate dehydrogenase
  • Peroxide metabolism

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